Logistic 回归分析肾综合征出血热并发急性胰腺炎的危险因素。

Logistic regression analysis of risk factors for hemorrhagic fever with renal syndrome complicated with acute pancreatitis.

机构信息

Department of Infectious Diseases, The First Affiliated Hospital of Wannan Medical College, Wuhu, Anhui, P. R. China.

Department of Public Health, Wannan Medical College, Wuhu, Anhui, P. R. China.

出版信息

Ann Med. 2023 Dec;55(1):2232355. doi: 10.1080/07853890.2023.2232355.

DOI:10.1080/07853890.2023.2232355

PMID:37431612

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10337492/

Abstract

BACKGROUND

Hantavirus infection is the main cause of hemorrhagic fever with renal syndrome (HFRS), which is common in Asia and Europe. There is a considerable risk of morbidity and mortality from the uncommon Hantavirus complication known as acute pancreatitis (AP).

METHODS

Retrospective analysis of the medical records of individuals with HFRS was performed. Relevant variables were assessed by univariate analyses and the variables with a value <.05 were entered into the multivariable regression analysis.

RESULTS

In this study, 114 individuals with HFRS in total were included, and 30 of them (26.32%) had AP. The univariate analyses showed that living in Xuancheng city (Anhui Province); an alcohol consumption history; white blood cell (WBC) count; lymphocyte (lym%) and eosinophil percentages (EO%); neutrophil (neut), eosinophil (EO), and red blood cell (RBC) counts; hemoglobin (Hb); hematocrit (HCT); proteinuria; hematuria; albumin (ALB), blood urea nitrogen (BUN), creatinine (Cr), uric acid (UA), cystatin-C (Cys-C) levels; carbon dioxide-combining power (COCP); fibrinogen degradation products (FDPs); and D-dimer level were significantly associated with HFRS complicated with AP ( < .05). In the multivariable regression analysis, an alcohol consumption history, lym%, proteinuria, FDPs and D-dimer level were found to be risk factors for HFRS complicated with AP ( < .05).

CONCLUSION

Our findings indicate that HFRS patients with a history of consuming alcohol, a high lym%, intense proteinuria, high levels of FDPs, and a low level of D-dimer might be more prone to the development of AP.KEY MESSAGESThis is the first report employing Logistic regression analysis methods for exploring the risk factors for HFRS complicated with AP in China.Many factors (most are laboratory parameters) were significantly associated with HFRS complicated with AP.We found that HFRS patients with a history of consuming alcohol, a high lym%, intense proteinuria, high levels of FDPs, and a low level of D-dimer might be more prone to the development of AP.

摘要

背景

汉坦病毒感染是肾综合征出血热（HFRS）的主要病因，在亚洲和欧洲较为常见。由汉坦病毒引起的一种不常见并发症——急性胰腺炎（AP），具有相当高的发病率和死亡率。

方法

对 HFRS 患者的病历进行回顾性分析。采用单因素分析评估相关变量，将 P 值<.05 的变量纳入多变量回归分析。

结果

本研究共纳入 114 例 HFRS 患者，其中 30 例（26.32%）并发 AP。单因素分析显示，居住地为宣城市（安徽省）、有饮酒史、白细胞（WBC）计数、淋巴细胞（lym%）和嗜酸性粒细胞百分比（EO%）、中性粒细胞（neut）、嗜酸性粒细胞（EO）和红细胞（RBC）计数、血红蛋白（Hb）、血细胞比容（HCT）、蛋白尿、血尿、白蛋白（ALB）、血尿素氮（BUN）、肌酐（Cr）、尿酸（UA）、胱抑素 C（Cys-C）水平、二氧化碳结合力（COCP）、纤维蛋白降解产物（FDPs）、D-二聚体水平与 HFRS 并发 AP 显著相关（<.05）。多变量回归分析显示，饮酒史、lym%、蛋白尿、FDPs 和 D-二聚体水平是 HFRS 并发 AP 的危险因素（<.05）。