Tai Yong, Zang Yanzi, Liu Tongxun, Ma Jiqing, Qin Litao, Ji Yuzi, Dai Hanqing, Wang Guangke, Ma Lingcao, Liu Fei
Department of Otorhinolaryngology, People's Hospital of Zhengzhou University, Zhengzhou University, Zhengzhou, China.
Department of Otorhinolaryngology, Zhongmu County People's Hospital, Zhengzhou, China.
Int Wound J. 2024 Apr;21(4):e14706. doi: 10.1111/iwj.14706.
To analyse the risk factors and healing factors of pharyngocutaneous fistula (PCF) in patients with laryngeal cancer after total laryngectomy, and to explore the relevant epidemiology. A retrospective analysis was conducted on laryngeal cancer patients who underwent total laryngectomy in our hospital from January 2010 to December 2022. The 349 patients included in the study were divided into a PCF group of 79 and a non-PCF group of 270. Perform one-way analysis of variance and multivariate logistic analysis on various data of patients included in the statistics, and analyse the risk factors and healing factors of PCF. Smoking, history of radiation therapy for laryngeal cancer, history of chemotherapy for laryngeal cancer, tumour location (larynx, pharynx, oesophagus), preoperative albumin, postoperative proteinaemia, <99 haemoglobin, postoperative haemoglobin, postoperative C-reactive protein (CRP) level are the risk factors for PCF. Also, radiation therapy and postoperative proteinaemia were the main reasons for preventing PCF healing. Smoking history, laryngeal cancer, radiation therapy, albumin, haemoglobin and CRP are risk factors for postoperative PCF after total laryngectomy, while radiation therapy and postoperative hypoalbuminaemia are key factors affecting PCF healing.
分析喉癌全喉切除术后咽瘘（PCF）患者的危险因素及愈合因素，并探讨相关流行病学情况。对2010年1月至2022年12月在我院接受全喉切除术的喉癌患者进行回顾性分析。纳入研究的349例患者分为咽瘘组79例和非咽瘘组270例。对纳入统计的患者各项数据进行单因素方差分析和多因素Logistic分析，分析咽瘘的危险因素及愈合因素。吸烟、喉癌放疗史、喉癌化疗史、肿瘤部位（喉、咽、食管）、术前白蛋白、术后蛋白血症、血红蛋白＜99、术后血红蛋白、术后C反应蛋白（CRP）水平是咽瘘的危险因素。此外，放疗和术后蛋白血症是阻碍咽瘘愈合的主要原因。吸烟史、喉癌、放疗、白蛋白、血红蛋白及CRP是全喉切除术后咽瘘的危险因素，而放疗和术后低蛋白血症是影响咽瘘愈合的关键因素。
