Complication Research, Steno Diabetes Center Copenhagen, Capital Region, Denmark.
Clinical Epidemiology, Steno Diabetes Center Copenhagen, Capital Region, Denmark.
Diabetes Care. 2023 Nov 1;46(11):1897-1902. doi: 10.2337/dc23-0475.
Diabetic ketoacidosis (DKA) is a life-threatening but preventable complication in people with type 1 diabetes. We aimed to quantify the incidence of DKA according to age and describe the time trend of DKA among adults with type 1 diabetes in Denmark.
Individuals aged ≥18 years with type 1 diabetes were identified from a nationwide Danish diabetes register. Hospital admissions due to DKA were ascertained from the National Patient Register. The follow-up period was from 1996 to 2020.
The cohort consisted of 24,718 adults with type 1 diabetes. The incidence rate of DKA per 100 person-years (PY) decreased with increasing age for both men and women. From 20 to 80 years of age, the DKA incidence rate decreased from 3.27 to 0.38 per 100 PY. From 1996 to 2008, the incidence rate of DKA increased for all age-groups, with a subsequent minor decrease in incidence rate until 2020. From 1996 to 2008, the incidence rates increased from 1.91 to 3.77 per 100 PY for a 20-year-old individual and from 0.22 to 0.44 per 100 PY for an 80-year-old individual living with type 1 diabetes. From 2008 to 2020 the incidence rates decreased from 3.77 to 3.27 and from 0.44 to 0.38 per 100 PY, respectively.
The incidence rates of DKA are declining for all ages, with an overall decline from 2008 for both men and women. This likely reflects improved diabetes management for individuals with type 1 diabetes in Denmark.
糖尿病酮症酸中毒（DKA）是 1 型糖尿病患者一种危及生命但可预防的并发症。本研究旨在根据年龄量化 DKA 的发病率，并描述丹麦 1 型糖尿病成人患者中 DKA 的时间趋势。
从丹麦全国性糖尿病登记处确定年龄≥18 岁的 1 型糖尿病患者。通过国家患者登记处确定因 DKA 住院的情况。随访时间为 1996 年至 2020 年。
该队列包括 24718 名 1 型糖尿病成人患者。男性和女性的 DKA 发病率均随年龄增长而降低。从 20 岁到 80 岁，DKA 发病率从每 100 人年 3.27 降至 0.38。从 1996 年至 2008 年，所有年龄段的 DKA 发病率均升高，随后发病率略有下降，直至 2020 年。从 1996 年至 2008 年，20 岁个体的发病率从每 100 人年 1.91 升至 3.77，80 岁个体的发病率从每 100 人年 0.22 升至 0.44。从 2008 年至 2020 年，发病率分别从每 100 人年 3.77 降至 3.27 和从 0.44 降至 0.38。
所有年龄段的 DKA 发病率均在下降，男女发病率均从 2008 年开始下降。这可能反映出丹麦 1 型糖尿病患者的糖尿病管理得到了改善。
