State Key Laboratory of Reliability and Intelligence of Electrical Equipment, School of Health Sciences and Biomedical Engineering, Hebei University of Technology, Tianjin 300130, China.
Department of Engineering Science and Mechanics, The Pennsylvania State University, University Park, Pennsylvania 16802, United States.
ACS Appl Mater Interfaces. 2023 Jul 26;15(29):34332-34342. doi: 10.1021/acsami.3c02485. Epub 2023 Jul 11.
Wearable electrochemical sensors provide means to detect molecular-level information from the biochemical markers in biofluids for physiological health evaluation. However, a high-density array is often required for multiplexed detection of multiple markers in complex biofluids, which is challenging with low-cost fabrication methods. This work reports the low-cost direct laser writing of porous graphene foam as a flexible electrochemical sensor to detect biomarkers and electrolytes in sweat. The resulting electrochemical sensor exhibits high sensitivity and low limit of detection for various biomarkers (e.g., the sensitivity of 6.49/6.87/0.94/0.16 μA μM cm and detection limit of 0.28/0.26/1.43/11.3 μM to uric acid/dopamine/tyrosine/ascorbic acid) in sweat. The results from this work open up opportunities for noninvasive continuous monitoring of gout, hydration status, and drug intake/overdose.
可穿戴电化学传感器为从生物流体中的生化标志物检测分子水平信息提供了手段，可用于生理健康评估。然而，在复杂的生物流体中对多种标志物进行多重检测通常需要高密度阵列，这对于低成本制造方法来说具有挑战性。本工作报道了低成本的直接激光写入多孔石墨烯泡沫作为一种用于检测汗液中生物标志物和电解质的柔性电化学传感器。所得到的电化学传感器对各种生物标志物（例如尿酸/多巴胺/酪氨酸/抗坏血酸的灵敏度分别为 6.49/6.87/0.94/0.16 μA μM cm 和检测限分别为 0.28/0.26/1.43/11.3 μM）表现出高灵敏度和低检测限。这项工作为非侵入性连续监测痛风、水合状态以及药物摄入/过量开辟了机会。
