Department of Chemical and Surfactant Technology, Institute of Advanced Chemistry of Catalonia (IQAC-CSIC), C/Jordi Girona 18-26, 08034 Barcelona, Spain; Bicosome S.L. C/Jordi Girona 18-26, 08034 Barcelona, Spain.
Department of Chemical and Surfactant Technology, Institute of Advanced Chemistry of Catalonia (IQAC-CSIC), C/Jordi Girona 18-26, 08034 Barcelona, Spain.
Eur J Pharm Biopharm. 2023 Sep;190:24-34. doi: 10.1016/j.ejpb.2023.07.004. Epub 2023 Jul 9.
The development of biocompatible delivery systems is a necessity for medical and topical applications. Herein, the development of a new bigel for topical application is described. It is composed of 40% colloidal lipid hydrogel and 60% olive oil and beeswax oleogel. Its characterization and the potential of the bigel as a drug carrier through the skin was evaluated in vitro using fluorescence microscopy and two phases of the bigel were labeled with two fluorescent probes: sodium fluorescein (hydrophilic phase) and Nile red (lipophilic phase). The structure of the bigel showed two phases with fluorescence microscopy in which the hydrogel phase was incorporated into a continuous oleogel matrix. Attenuated Total Reflectance Fourier Transform Infrared Spectroscopy (ATR-FTIR) presented a combination of vibrations characteristic of the different molecules forming the bigel, and Differential Scanning Calorimetry (DSC) showed different transitions attributed to beeswax lipids. Small-angle and wide-angle X-ray scattering (SAXS and WAXS) indicated a predominant lamellar structure with orthorhombic lateral packing that could be related to the arrangement of beeswax crystals. Bigel enables deeper penetration of hydrophilic and lipophilic probes into deeper layers, making it a promising candidate for effective topical carriers in medical and dermatological applications.
开发生物相容的递药系统是医学和局部应用的必然需求。本文描述了一种新型局部用双凝胶的开发。它由 40%胶体脂质水凝胶和 60%橄榄油-蜂蜡油凝胶组成。通过荧光显微镜和双凝胶的两个相分别用两种荧光探针（亲水性相的荧光素钠和疏水性相的尼罗红）对其进行了表征，并评估了其作为经皮药物载体的潜力。荧光显微镜下双凝胶的结构显示出两相，其中水凝胶相嵌入连续的油凝胶基质中。衰减全反射傅里叶变换红外光谱（ATR-FTIR）呈现出形成双凝胶的不同分子的振动特征的组合，差示扫描量热法（DSC）显示出归因于蜂蜡脂质的不同转变。小角和广角 X 射线散射（SAXS 和 WAXS）表明存在占主导地位的层状结构，具有正交的层状堆积，这可能与蜂蜡晶体的排列有关。双凝胶能够使亲水性和疏水性探针更深地渗透到更深的层中，使其成为医学和皮肤病学应用中有效局部载体的有前途的候选物。
