Soltanzadi Atena, Mirmosayyeb Omid, Momeni Moghaddam Amin, Ghoshouni Hamed, Ghajarzadeh Mahsa
Radiology Department, Taleghani Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Isfahan Neurosciences Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.
Neurologia (Engl Ed). 2024 Nov-Dec;39(9):802-809. doi: 10.1016/j.nrleng.2023.06.002. Epub 2023 Jul 9.
To estimate the pooled incidence of Bell's palsy after COVID-19 vaccination.
PubMed, Scopus, EMBASE, Web of Science, and Google Scholar were searched by 2 independent researchers. We also searched the grey literature including references of the references and conference abstracts. We extracted data regarding the total number of participants, first author, publication year, the country of origin, sex, type of vaccines, and the number of patients who developed Bell's palsy after COVID-19 vaccination.
The literature search revealed 370 articles, subsequently deleting duplicates 227 remained. After careful evaluation of the full texts, 20 articles remained for meta-analysis. The most commonly administered vaccines were Pfizer followed by Moderna. In total, 4.54e+07 individuals received vaccines against COVID-19, and 1739 cases developed Bell's palsy. In nine studies, controls (individuals without vaccination) were enrolled. The total number of controls was 1 809 069, of whom 203 developed Bell's palsy. The incidence of Bell's palsy after COVID-19 vaccines was ignorable. The odds of developing Bell's palsy after COVID-19 vaccines was 1.02 (95% CI: 0.79-1.32) (I2 = 74.8%, P < .001).
The results of this systematic review and meta-analysis show that the incidence of peripheral facial palsy after COVID-19 vaccination is ignorable and vaccination does not increase the risk of developing Bell's palsy. Maybe, Bell's palsy is a presenting symptom of a more severe form of COVID-19, so clinicians must be aware of this.
评估新冠疫苗接种后贝尔麻痹的合并发病率。
两名独立研究人员检索了PubMed、Scopus、EMBASE、Web of Science和谷歌学术。我们还检索了灰色文献，包括参考文献的参考文献和会议摘要。我们提取了有关参与者总数、第一作者、出版年份、原产国、性别、疫苗类型以及新冠疫苗接种后发生贝尔麻痹的患者数量的数据。
文献检索共找到370篇文章，删除重复项后还剩227篇。经过对全文的仔细评估，最终有20篇文章纳入荟萃分析。最常用的疫苗是辉瑞，其次是莫德纳。共有4.54×10⁷人接种了新冠疫苗，其中1739例发生了贝尔麻痹。在9项研究中纳入了对照组（未接种疫苗的个体）。对照组总数为1809069人，其中203例发生了贝尔麻痹。新冠疫苗接种后贝尔麻痹的发病率可忽略不计。接种新冠疫苗后发生贝尔麻痹的比值比为1.02（95%CI：0.79 - 1.32）（I² = 74.8%，P < 0.001）。
本系统评价和荟萃分析结果表明，新冠疫苗接种后周围性面瘫的发病率可忽略不计，接种疫苗不会增加发生贝尔麻痹的风险。也许，贝尔麻痹是更严重形式的新冠的一种表现症状，因此临床医生必须对此有所认识。
