Burzynski S R, Kubove E
Drugs Exp Clin Res. 1986;12 Suppl 1:47-55.
Antineoplaston A10 injections were administered to 18 patients diagnosed with 19 types of neoplastic disease. The patients' diagnoses included: adenocarcinoma of the rectum and colon, Stage IV (8 cases); adenocarcinoma of the pancreas (4 cases); adenocarcinoma of the breast, Stage IV (3 cases) and single cases of adenocarcinoma of the lungs, Stage III; adenocarcinoma of the stomach, Stage IV; chondrosarcoma of the nose and right maxillary sinus; and carcinoid. The treatment was administered from 52 to 640 days. The highest dosage taken was 2210.5 mg/kg/24 h. Most of the patients were taking from 206.9 to 387.1 mg/kg/24 h. The treatment was associated with minimal side-effects including febrile reactions, muscle and joint pain, muscle contraction in the throat, abdominal pain of short duration and single incidences of nausea, dizziness and headache. Desirable side-effects included increase of platelet count and white blood cell count. Objective response to the treatment was noticed in 8 patients including one patient diagnosed with intraductal carcinoma of the breast, Stage IV, 2 patients with adenocarcinoma of the sigmoid, Stage IV, 1 patient with adenocarcinoma of the rectum, Stage IV, 2 patients with adenocarcinoma of the pancreas, 1 patient with adenocarcinoma of the lung, Stage III, and 1 chondrosarcoma.
对18名被诊断患有19种肿瘤疾病的患者进行了抗瘤氨酸A10注射治疗。患者的诊断包括：直肠和结肠癌，IV期（8例）；胰腺癌（4例）；乳腺癌，IV期（3例）以及肺癌III期、胃癌IV期、鼻和右上颌窦软骨肉瘤、类癌各1例。治疗持续了52至640天。最高服用剂量为2210.5毫克/千克/24小时。大多数患者服用剂量为206.9至387.1毫克/千克/24小时。该治疗的副作用极小，包括发热反应、肌肉和关节疼痛、喉咙肌肉收缩、短暂腹痛以及偶尔出现的恶心、头晕和头痛。有益的副作用包括血小板计数和白细胞计数增加。8名患者对治疗有客观反应，其中包括1例IV期乳腺导管内癌患者、2例IV期乙状结肠癌患者、1例IV期直肠癌患者、2例胰腺癌患者、1例III期肺癌患者和1例软骨肉瘤患者。
