雾化肺表面活性物质治疗呼吸窘迫成功的预测因素。
Predictors of successful treatment of respiratory distress with aerosolized calfactant.
机构信息
Johns Hopkins All Children's Hospital, Maternal, Fetal and Neonatal Institute, St. Petersburg, FL, USA.
Department of Pediatrics, Division of Neonatology and Newborn Nursery, University of Wisconsin-Madison, Madison, WI, USA.
出版信息
J Perinatol. 2023 Aug;43(8):991-997. doi: 10.1038/s41372-023-01722-4. Epub 2023 Jul 11.
INTRODUCTION
Predictors for successful aerosolized surfactant treatment are not well defined.
OBJECTIVE
To identify predictors for successful treatment in the AERO-02 trial and the AERO-03 expanded access program.
METHODS
Neonates receiving nasal continuous positive airway pressure (NCPAP) at the time of first aerosolized calfactant administration were included in this analysis. Associations between demographic and clinical predictors to need for intubation were examined using univariate testing and multivariate logistic regression analyses.
RESULTS
Three hundred and eighty infants were included in the study. Overall, 24% required rescue by intubation. Multivariate modeling revealed that the predictors of successful treatment were a gestational age ≥31 weeks, a respiratory severity score (RSS) of <1.9, and <2 previous aerosol treatments.
CONCLUSION
Gestational age, number of aerosols, and RSS are predictive of successful treatment. These criteria will help select patients most likely to benefit from aerosolized surfactant.
引言
成功的雾化表面活性剂治疗的预测因素尚未明确。
目的
在 AERO-02 试验和 AERO-03 扩大准入计划中确定治疗成功的预测因素。
方法
在首次给予雾化肺表面活性剂时接受鼻持续气道正压通气（NCPAP）的新生儿被纳入本分析。使用单变量检验和多变量逻辑回归分析来检查与需要插管相关的人口统计学和临床预测因素之间的关联。
结果
本研究共纳入 380 名婴儿。总体而言，24%的婴儿需要通过插管进行抢救。多变量建模显示，成功治疗的预测因素是胎龄≥31 周、呼吸严重程度评分（RSS）<1.9 且<2 次雾化治疗。
结论
胎龄、气溶胶数量和 RSS 可预测治疗效果。这些标准将有助于选择最有可能从雾化表面活性剂中受益的患者。
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