使用米氏动力学预测苯妥英水平时的注意事项。
Precautions in the use of Michaelis-Menten kinetics in the prediction of phenytoin levels.
作者信息
Jochsberger T
出版信息
Drug Intell Clin Pharm. 1986 Jul-Aug;20(7-8):605-6. doi: 10.1177/106002808602000725.
PMID:3743419
Abstract
The Michaelis-Menten equation is one of the various techniques available for predicting steady-state plasma levels of phenytoin. In actual practice, however, data are not always available or reliable. This case report emphasizes the importance of establishing the quality of the data and determining that steady state has been achieved. The addition of a third point to the graph used to estimate parameters greatly increases prediction accuracy.
摘要
米氏方程是预测苯妥英稳态血药浓度的多种方法之一。然而，在实际应用中，数据并非总是可得或可靠的。本病例报告强调了确定数据质量以及判断是否已达到稳态的重要性。在用于估计参数的图表上增加第三个点可大大提高预测准确性。
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