Kaczor Agnieszka
Faculty of Chemistry, Jagiellonian University, Gronostajowa 2, 30-387, Krakow, Poland.
Phys Chem Chem Phys. 2023 Jul 26;25(29):19371-19379. doi: 10.1039/d3cp01961f.
Vibrational optical activity (VOA) refers to two vibrational techniques: vibrational circular dichroism (VCD) and Raman optical activity (ROA) that are sensitive both to the chirality and the molecular structure, typically surpassing electronic optical activity (EOA) in recognition of fine structural details. However, the measurement of VOA is inherently obstructed as the intensity of the VOA signal is typically 10-10 of the intensity of the parent IR or Raman signals. This feature considerably limits the practical applications of VOA and is a fundamental reason why various strategies are currently developed to enhance the VOA intensity. This perspective review discusses up-to-date studies focusing on applications of VOA to analyse supramolecular, mostly biogenic, systems showing induction and amplification of chirality. Most attention is devoted to two types of biogenic supramolecular assemblies providing unique enhancement of VOA: amyloid fibrils showing enormous VCD and carotenoid aggregates exhibiting resonantly enhanced ROA.
振动光学活性（VOA）指的是两种振动技术：振动圆二色性（VCD）和拉曼光学活性（ROA），它们对手性和分子结构都很敏感，在识别精细结构细节方面通常超过电子光学活性（EOA）。然而，VOA的测量存在固有障碍，因为VOA信号的强度通常是母红外或拉曼信号强度的10^-10 。这一特性极大地限制了VOA的实际应用，也是目前开发各种策略来增强VOA强度的根本原因。这篇观点综述讨论了最新的研究，这些研究聚焦于VOA在分析超分子（主要是生物源）系统中的应用，这些系统显示出手性的诱导和放大。大部分注意力集中在两种类型的生物源超分子聚集体上，它们能独特地增强VOA：显示出巨大VCD的淀粉样纤维和表现出共振增强ROA的类胡萝卜素聚集体。
