Ye Xianhua, Zheng Saisai, Huang Xiaoyan, Yan Qiaoqin
Department of Anesthesiology, The First People's Hospital of Wenling Taizhou, Zhejiang, China.
Department of Gastrointestinal Surgery, The First People's Hospital of Wenling Taizhou, Zhejiang, China.
Am J Transl Res. 2023 Jun 15;15(6):4237-4245. eCollection 2023.
To investigate the effects of electroacupuncture pre-stimulation on perioperative neurocognitive disorders (PNDs) in patients undergoing colon cancer surgery.
A total of 80 elderly patients with colon cancer undergoing elective surgery were selected as subjects. Patients in an observation group (N=40) were given electroacupuncture pre-stimulation at Baihui and Dazhui points, while those in a control group (N=40) were given sham electroacupuncture pre-stimulation. The Mini-Mental State Examination (MMSE), self-rating anxiety scale (SAS), Activity of Daily Living Scale (ADL), as well as the levels of microtubule-associated protein light chain 3II (LC3-II), Bcl-2 homologous domain protein antibody 1 (Beclin-1) and central nerve specific protein S100β before and after treatment were compared.
Compared with those before treatment, no significant differences were found in the scores of MMSE, SAS and ADL at 7 d after treatment in both groups, while MMSE scores were significantly lower and the scores of SAS and ADL were obviously more at 1 d and 3 d after treatment in both groups. Moreover, at 1 d and 3 d after treatment, the MMSE score in the observation group was significantly higher than that in the control group, while the scores of SAS and ADL in the observation group were lower than those in the control group (all P<0.05). Compared with those after treatment in the control group, the level of S100β was significantly decreased, while the levels of LC3-II and Beclin-1 were obviously increased in the observation group (all P<0.05).
Electroacupuncture pre-stimulation at Baihui and Dazhui points could effectively reduce neurological damage and prevent PNDs in patients undergoing colon cancer surgery through improving the cognitive functions, anxiety states and self-care ability. The observed changes in levels of S100β, LC3-II and Beclin-1 may be associated with the beneficial effects of electroacupuncture pre-stimulation on PNDs in these patients.
探讨电针预刺激对结肠癌手术患者围手术期神经认知障碍（PND）的影响。
选取80例择期行结肠癌手术的老年患者作为研究对象。观察组（N = 40）患者于百会穴和大椎穴给予电针预刺激，对照组（N = 40）患者给予假电针预刺激。比较两组患者治疗前后的简易精神状态检查表（MMSE）、焦虑自评量表（SAS）、日常生活活动能力量表（ADL），以及微管相关蛋白轻链3II（LC3-II）、Bcl-2同源结构域蛋白抗体1（Beclin-1）和中枢神经特异性蛋白S100β水平。
与治疗前相比，两组患者治疗后7 d时MMSE、SAS和ADL评分差异均无统计学意义，而两组患者治疗后1 d和3 d时MMSE评分均显著降低，SAS和ADL评分明显升高。此外，治疗后1 d和3 d时，观察组MMSE评分显著高于对照组，而观察组SAS和ADL评分低于对照组（均P < 0.05）。与对照组治疗后相比，观察组S100β水平显著降低，而LC3-II和Beclin-1水平明显升高（均P < 0.05）。
百会穴和大椎穴电针预刺激可有效减轻神经损伤，通过改善认知功能、焦虑状态和自我护理能力预防结肠癌手术患者发生PND。观察到的S100β、LC3-II和Beclin-1水平变化可能与电针预刺激对这些患者PND的有益作用有关。
