Soltani Bajestani Farhang, Khajavian Nasim, Salarbashi Davoud, Kafili Mojtaba, Ashori Fatemeh, Hajavi Jafar
Department of Rheumatology, Faculty of Medicine, Gonabad University of Medical Sciences, Gonabad, Iran.
Department of Epidemiology and Biostatistics, School of Health and Research Center for Social Determinants of Health, Gonabad University of Medical Sciences, Gonabad, Iran.
Clin Med Insights Arthritis Musculoskelet Disord. 2023 Jul 6;16:11795441231182997. doi: 10.1177/11795441231182997. eCollection 2023.
Rheumatoid arthritis is an autoimmune disease that causes joint pain and reduces daily activities. The aim of this study was to evaluate the serum of vitamin D and its relationship with the severity of the disease in patients with rheumatoid arthritis referred to Allameh Hehlool hospital in Gonabad.
This cross-sectional-analytical study was performed on 92 patients referred to the rheumatology clinic of Allameh Behlool Gonabad Hospital in 2021. After obtaining the permission of the ethics committee, the samples were selected based on the desired criteria. Serum vitamin D levels in patients were measured, and data were collected using a patient information checklist and DAS28-CRP activity questionnaire. Data were analyzed using SPSS software version 16 and using statistically appropriate tests at a significance level less than 5%.
The mean age of the patients was 53.05 ± 12.33 years and most of them (58.7%) were women. Serum vitamin D level was sufficient in 65.2% of patients and the severity of the disease was in the remission in 48.9% of them. The results of chi-square test showed a significant relationship between serum vitamin D levels and disease severity in patients ( < .001).
Serum vitamin D levels were inversely related to disease severity and in most patients with severe disease severity, serum vitamin D levels were inadequate. vitamin D supplementation is recommended in patients with rheumatoid arthritis.
类风湿性关节炎是一种自身免疫性疾病，会导致关节疼痛并降低日常活动能力。本研究的目的是评估前往戈纳巴德阿拉梅赫·赫洛勒医院就诊的类风湿性关节炎患者的血清维生素D水平及其与疾病严重程度的关系。
本横断面分析研究于2021年对92名前往阿拉梅赫·贝赫洛勒戈纳巴德医院风湿病门诊就诊的患者进行。在获得伦理委员会许可后，根据所需标准选取样本。测量患者的血清维生素D水平，并使用患者信息清单和DAS28-CRP活动问卷收集数据。使用SPSS软件16版进行数据分析，并在显著性水平小于5%的情况下使用统计学上合适的检验方法。
患者的平均年龄为53.05±12.33岁，其中大多数（58.7%）为女性。65.2%的患者血清维生素D水平充足，48.9%的患者疾病处于缓解期。卡方检验结果显示患者血清维生素D水平与疾病严重程度之间存在显著关系（<0.001）。
血清维生素D水平与疾病严重程度呈负相关，在大多数疾病严重程度较高的患者中，血清维生素D水平不足。建议类风湿性关节炎患者补充维生素D。
