Kaplan Huseyin, Calis Mustafa, Yazici Cevat, Gunturk Inayet, Cuce Isa, Senel Abdurrahman Soner
Division of Rheumatology, Department of Physical Medicine and Rehabilitation, Erciyes University Faculty of Medicine, Kayseri, Turkiye.
Department of Physical Medicine and Rehabilitation, Erciyes University Faculty of Medicine, Kayseri, Turkiye.
North Clin Istanb. 2023 Jun 6;10(3):306-313. doi: 10.14744/nci.2022.54189. eCollection 2023.
Follistatin-like protein 1 (FSTL-1) and follistatin-like protein 3 (FSTL-3) are glycoproteins whose associations with inflammatory cytokines were reported in previous studies. However, it is not yet known whether they have an effect on the pathogenesis of familial Mediterranean fever (FMF). We aimed to detect the FSTL-1 and FSTL-3 levels and to determine their relationship to the attack status and mutation types in patients with FMF.
Fifty-six FMF patients and 22 healthy controls (HCs) were included in the study. Serum FSTL-1 and FSTL-3 levels were measured with the enzyme-linked immunosorbent assay method from collected serum samples. In addition, the MEditerranean FeVer (MEFV) gene mutation types of the patients were noted.
Serum FSTL-1 levels were significantly higher in FMF patients than in HCs (p=0.005). However, there was no significant difference in FSTL-1 levels between patients in the attack period (n=26) and in the attack-free period (n=30). FSTL-3 levels were similar between FMF patients and HCs or patients in the attack period and in the attack-free period. Furthermore, the MEFV mutation type and attack status had no significant effect on FSTL-1 and FSTL-3 levels (p>0.05).
Our results suggest that FSTL-1 may be associated with the pathogenesis of FMF, rather than FSTL-3. However, neither serum FSTL-1 nor FSTL-3 seems to be good markers to reflect inflammatory activity.
卵泡抑素样蛋白1（FSTL-1）和卵泡抑素样蛋白3（FSTL-3）是糖蛋白，先前的研究报道了它们与炎性细胞因子的关联。然而，它们是否对家族性地中海热（FMF）的发病机制有影响尚不清楚。我们旨在检测FMF患者的FSTL-1和FSTL-3水平，并确定它们与发作状态及突变类型的关系。
本研究纳入了56例FMF患者和22例健康对照（HC）。采用酶联免疫吸附测定法从采集的血清样本中检测血清FSTL-1和FSTL-3水平。此外，记录患者的地中海热（MEFV）基因突变类型。
FMF患者的血清FSTL-1水平显著高于HC（p=0.005）。然而，发作期患者（n=26）和非发作期患者（n=30）的FSTL-水平无显著差异。FMF患者与HC之间或发作期与非发作期患者之间的FSTL-3水平相似。此外，MEFV突变类型和发作状态对FSTL-1和FSTL-3水平无显著影响（p>0.05）。
我们的结果表明，FSTL-1可能与FMF的发病机制相关，而非FSTL-3。然而，血清FSTL-1和FSTL-3似乎都不是反映炎症活动的良好标志物。
