在低水平的N-甲基-N'-硝基-N-亚硝基胍存在下生长后，甲苯处理的大肠杆菌中脱氧核糖核酸聚合酶I指导的修复合成增强。
Enhancement of deoxyribonucleic acid polymerase I-directed repair synthesis in toluene-treated Escherichia coli after growth in the presence of low levels of N-methyl-N'-nitro-N-nitrosoguanidine.
作者信息
Billen D, Hellermann G R
出版信息
J Bacteriol. 1979 Mar;137(3):1439-42. doi: 10.1128/jb.137.3.1439-1442.1979.
Abstract
Deoxyribonucleic acid polymerase I-directed repair synthesis can be selectively measured in toluene-treated Escherichia coli cells exposed to alkylating chemicals such as N-methyl-N'-nitro-N-nitrosoguanidine. Prior growth of the cells in the presence of a low dose of N-methyl-N'-nitro-N-nitrosoguanidine results in an enhanced deoxyribonucleic acid polymerase I-directed repair synthesis and an increase in single-strand breaks.
摘要
在暴露于诸如N-甲基-N'-硝基-N-亚硝基胍等烷基化化学物质的经甲苯处理的大肠杆菌细胞中，可以选择性地测量脱氧核糖核酸聚合酶I指导的修复合成。细胞在低剂量N-甲基-N'-硝基-N-亚硝基胍存在下预先生长会导致脱氧核糖核酸聚合酶I指导的修复合成增强以及单链断裂增加。
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