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在低水平的N-甲基-N'-硝基-N-亚硝基胍存在下生长后,甲苯处理的大肠杆菌中脱氧核糖核酸聚合酶I指导的修复合成增强。

Enhancement of deoxyribonucleic acid polymerase I-directed repair synthesis in toluene-treated Escherichia coli after growth in the presence of low levels of N-methyl-N'-nitro-N-nitrosoguanidine.

作者信息

Billen D, Hellermann G R

出版信息

J Bacteriol. 1979 Mar;137(3):1439-42. doi: 10.1128/jb.137.3.1439-1442.1979.

Abstract

Deoxyribonucleic acid polymerase I-directed repair synthesis can be selectively measured in toluene-treated Escherichia coli cells exposed to alkylating chemicals such as N-methyl-N'-nitro-N-nitrosoguanidine. Prior growth of the cells in the presence of a low dose of N-methyl-N'-nitro-N-nitrosoguanidine results in an enhanced deoxyribonucleic acid polymerase I-directed repair synthesis and an increase in single-strand breaks.

摘要

在暴露于诸如N-甲基-N'-硝基-N-亚硝基胍等烷基化化学物质的经甲苯处理的大肠杆菌细胞中,可以选择性地测量脱氧核糖核酸聚合酶I指导的修复合成。细胞在低剂量N-甲基-N'-硝基-N-亚硝基胍存在下预先生长会导致脱氧核糖核酸聚合酶I指导的修复合成增强以及单链断裂增加。

相似文献

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Enhancement of DNA polymerase II activity in E. coli after treatment with N-methyl-N'-nitro-N-nitrosoguanidine.
Biochem Biophys Res Commun. 1977 May 9;76(1):136-41. doi: 10.1016/0006-291x(77)91678-3.

本文引用的文献

4
New class of enzymes acting on damaged DNA.
Nature. 1976;259(5538):64-6. doi: 10.1038/259064a0.
7
A new pathway for DNA repair in Escherichia coli.
Nature. 1977 May 19;267(5608):281-3. doi: 10.1038/267281a0.
10
Depression by NAD of x-ray-induced repair-type DNA synthesis in toluene-treated Bacillus subtilis.
Biochim Biophys Acta. 1975 Apr 2;383(4):379-87. doi: 10.1016/0005-2787(75)90307-x.

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