开发并内部验证了一个用于预测宫颈癌幸存者生活质量的多变量预测模型。
Development and internal validation of a multivariable prediction model for the quality of life of cervical cancer survivors.
机构信息
Clinical Management Unit for Obstetrics and Gynecology, University Hospital Virgen Macarena, Seville, Spain.
Institute of Science and Technology, Loyola University, Seville, Spain.
出版信息
J Obstet Gynaecol Res. 2023 Oct;49(10):2446-2456. doi: 10.1111/jog.15743. Epub 2023 Jul 12.
PURPOSE
To elaborate a prediction model for quality of life of cervical cancer survivors.
METHODS
We conducted a prospective cohort study on 229 cervical cancer survivors. The quality of life measures included the Functional Assessment Cancer Therapy-Cervix version 4.0 and the World Health Organization Quality of Life-brief version self-administered questionnaires. We imported the data into the statistical software program R and developed a gamma generalized linear model.
RESULTS
Our internally validated predictive model for the Functional Assessment Cancer Therapy-Cervix total score was composed of the following predictors: pain, appetite, vaginal bleeding/discharge/odor, and WHOQOL-BREF social relationships domain. The Harrell's concordance index was 0.75.
CONCLUSIONS
We developed a solid and internally validated predictive model in cervical cancer survivors based on predictors, such as pain, appetite, vaginal bleeding/odor/discharge, and WHOQOL-BREF social relationships subscale score that contribute significantly to quality of life as targets for potential intervention.
目的
阐述宫颈癌生存者生活质量的预测模型。
方法
我们对 229 名宫颈癌生存者进行了前瞻性队列研究。生活质量评估包括宫颈癌功能评估量表 4.0（Functional Assessment Cancer Therapy-Cervix version 4.0）和世界卫生组织生活质量简表自我评估问卷。我们将数据导入统计软件程序 R 并开发了伽马广义线性模型。
结果
我们内部验证的宫颈癌生存者功能评估癌症治疗-宫颈总分预测模型由以下预测因子组成：疼痛、食欲、阴道出血/分泌物/气味和 WHOQOL-BREF 社会关系领域。哈雷尔一致性指数为 0.75。
结论
我们基于疼痛、食欲、阴道出血/分泌物/气味和 WHOQOL-BREF 社会关系子量表评分等预测因子，为宫颈癌生存者建立了一个可靠的内部验证预测模型，这些因子显著影响生活质量，可作为潜在干预的目标。
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