Family Medicine, School of Public Health and Community Medicine, Institute for Medicine.
Wallenberg Laboratory for Cardiovascular and Metabolic Research, Department of Molecular and Clinical Medicine, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg.
J Hypertens. 2023 Oct 1;41(10):1565-1570. doi: 10.1097/HJH.0000000000003506. Epub 2023 Jul 12.
To investigate the association between sex hormone-binding globulin (SHBG) levels, change in blood pressure and development of hypertension.
In a community-based study, we examined 2816 middle-aged participants with focus on cardiometabolic risk factors in 2002-2005. A representative sample of 1954 men and women was invited to follow-up in 2012-2014 and 1327 were included in a second study visit. Mean follow-up time was 9.7 years. Blood pressure was measured according to the guidelines from the seventh Joint National Committee of Hypertension, and new cases of hypertension were recorded. SHBG was measured at baseline. The association between SHBG, blood pressure and new cases of hypertension was investigated using linear regression analyses and logistic regression analyses after excluding individuals treated with blood pressure-lowering drugs.
Mean SBP and DBP at follow-up was 123 and 72 mmHg, respectively, and mean increase from baseline was 5.8 and 2.9 mmHg. During the follow-up time, 167 new cases of hypertension (16.1%) were identified. One standard deviation (SD) increase in SHBG at baseline was inversely associated with the risk to develop hypertension at follow-up (OR = 0.74, 95% CI 0.58-0.95) in the fully adjusted model. Moreover, one SD increase in SHBG was associated with a decrease in mean SBP (delta = -1.5 mmHg, 95% CI - 2.2 to -0.8) and DBP (delta = - 1.0 mmHg, 95% CI - 1.5 to -0.4), after adjusting for covariates.
SHBG levels are inversely associated with development of hypertension and change in blood pressure levels independent of major risk factors.
研究性激素结合球蛋白 (SHBG) 水平与血压变化和高血压发展之间的关系。
在一项基于社区的研究中，我们检查了 2002-2005 年期间 2816 名患有代谢心血管危险因素的中年参与者。邀请了 1954 名男性和女性的代表性样本参加 2012-2014 年的随访，其中 1327 名纳入第二次研究访问。平均随访时间为 9.7 年。血压按照第七次联合国家高血压委员会的指南进行测量，并记录新的高血压病例。在排除接受降压药物治疗的个体后，使用线性回归分析和逻辑回归分析研究了基线时 SHBG 与血压和新高血压病例之间的关系。
随访时的平均 SBP 和 DBP 分别为 123 和 72mmHg，平均基线增加 5.8 和 2.9mmHg。在随访期间，确定了 167 例新的高血压病例（16.1%）。基线时 SHBG 增加一个标准差与随访时发生高血压的风险呈负相关（OR=0.74，95%CI 0.58-0.95），在完全调整模型中。此外，SHBG 增加一个标准差与平均 SBP（差值=-1.5mmHg，95%CI-2.2 至-0.8）和 DBP（差值=-1.0mmHg，95%CI-1.5 至-0.4）降低相关，调整了协变量。
SHBG 水平与高血压的发展以及血压水平的变化呈负相关，独立于主要危险因素。
