Department of Epidemiology, College of Public Health, University of Iowa, Iowa City, Iowa.
Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, Miami, Florida.
Cancer Epidemiol Biomarkers Prev. 2023 Oct 2;32(10):1312-1322. doi: 10.1158/1055-9965.EPI-23-0218.
BACKGROUND: Racial and ethnic disparities in guideline-recommended breast cancer treatment are well documented, however studies including diagnostic and staging procedures necessary to determine treatment indications are lacking. The purpose of this study was to characterize patterns in delivery of evidence-based services for the diagnosis, clinical workup, and first-line treatment of breast cancer by race-ethnicity. METHODS: SEER-Medicare data were used to identify women diagnosed with invasive breast cancer between 2000 and 2017 at age 66 or older (n = 2,15,605). Evidence-based services included diagnostic procedures (diagnostic mammography and breast biopsy), clinical workup (stage and grade determination, lymph node biopsy, and HR and HER2 status determination), and treatment initiation (surgery, radiation, chemotherapy, hormone therapy, and HER2-targeted therapy). Poisson regression was used to estimate rate ratios (RR) and 95% confidence intervals (CI) for each service. RESULTS: Black and American Indian/Alaska Native (AIAN) women had significantly lower rates of evidence-based care across the continuum from diagnostics through first-line treatment compared to non-Hispanic White (NHW) women. AIAN women had the lowest rates of HER2-targeted therapy and hormone therapy initiation. While Black women also had lower initiation of HER2-targeted therapy than NHW, differences in hormone therapy were not observed. CONCLUSIONS: Our findings suggest patterns along the continuum of care from diagnostic procedures to treatment initiation may differ across race-ethnicity groups. IMPACT: Efforts to improve delivery of guideline-concordant treatment and mitigate racial-ethnic disparities in healthcare and survival should include procedures performed as part of the diagnosis, clinical workup, and staging processes.
背景:种族和民族差异在推荐的乳腺癌治疗指南中得到了充分证明,然而,包括确定治疗指征所需的诊断和分期程序在内的研究却缺乏。本研究的目的是描述种族和民族对乳腺癌诊断、临床评估和一线治疗的循证服务提供模式。
方法:使用 SEER-Medicare 数据,确定了 2000 年至 2017 年间年龄在 66 岁及以上被诊断患有浸润性乳腺癌的女性(n=215605)。循证服务包括诊断程序(诊断性乳房 X 线摄影和乳房活检)、临床评估(分期和分级确定、淋巴结活检、HR 和 HER2 状态确定)以及治疗启动(手术、放疗、化疗、激素治疗和 HER2 靶向治疗)。采用泊松回归估计每个服务的率比(RR)和 95%置信区间(CI)。
结果:与非西班牙裔白人(NHW)女性相比,黑人女性和美洲印第安人/阿拉斯加原住民(AIAN)女性在从诊断到一线治疗的整个过程中接受循证护理的比例明显较低。AIAN 女性接受 HER2 靶向治疗和激素治疗的比例最低。虽然黑人女性接受 HER2 靶向治疗的比例也低于 NHW 女性,但激素治疗没有差异。
结论:我们的研究结果表明,从诊断程序到治疗启动的护理连续体的模式可能因种族和民族群体而异。
影响:改善符合指南的治疗方案的提供并减轻医疗保健和生存方面的种族和民族差异的努力,应包括在诊断、临床评估和分期过程中进行的程序。
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