Interfaculty Institute of Biochemistry, University of Tübingen, Tübingen, Germany.
Cell Biology, RPTU, University of Kaiserslautern , Kaiserslautern, Germany.
J Cell Biol. 2023 Aug 7;222(8). doi: 10.1083/jcb.202306035. Epub 2023 Jul 12.
Tail-anchored proteins are tethered to membranes of the ER, mitochondria, and peroxisomes. In this issue, Pleiner and colleagues (2023. J. Cell Biol.https://doi.org/10.1083/jcb.202212007) show that the ER membrane complex (EMC) uses an inbuilt charge-dependent selectivity filter to specifically insert ER tail-anchored proteins according to their topology signals and to prevent the misincorporation of mitochondrial proteins.
尾部锚定蛋白被固定在内质网、线粒体和过氧化物酶体的膜上。在本期杂志中，Pleiner 及其同事（2023. J. Cell Biol.https://doi.org/10.1083/jcb.202212007）表明内质网膜复合物（EMC）利用内置的电荷依赖性选择性过滤器，根据拓扑信号特异性插入内质网尾部锚定蛋白，并防止线粒体蛋白的错误掺入。
