Oxa1 超家族介导的膜蛋白生物发生的结构和分子机制。
Structural and molecular mechanisms for membrane protein biogenesis by the Oxa1 superfamily.
机构信息
Heidelberg University Biochemistry Center (BZH), Heidelberg, Germany.
出版信息
Nat Struct Mol Biol. 2021 Mar;28(3):234-239. doi: 10.1038/s41594-021-00567-9. Epub 2021 Mar 4.
PMID:33664512
Abstract
Members of the Oxa1 superfamily perform membrane protein insertion in bacteria, the eukaryotic endoplasmic reticulum (ER), and endosymbiotic organelles. Here, we review recent structures of the three ER-resident insertases and discuss the extent to which structure and function are conserved with their bacterial counterpart YidC.
摘要
Oxa1 超家族的成员在细菌、真核内质网 (ER) 和共生细胞器中执行膜蛋白插入。在这里，我们回顾了最近三种 ER 驻留插入酶的结构，并讨论了其结构和功能与细菌对应物 YidC 的保守程度。
Zotero 插件