Department of Emergency and Critical Care, The Animal Medical Center, New York, New York, USA.
J Vet Emerg Crit Care (San Antonio). 2023 Jul-Aug;33(4):472-476. doi: 10.1111/vec.13313. Epub 2023 Jul 12.
To describe the successful treatment of severe neurological and cardiovascular abnormalities in a dog following ingestion of the neuropsychotropic drug, phenibut.
A 2-year-old neutered male Weimaraner was found unresponsive and laterally recumbent in his urine after ingesting approximately 1600 mg/kg of phenibut. On presentation to an emergency clinic, the dog was neurologically inappropriate, tachycardic, hypertensive, and exhibiting a profoundly decreased respiratory rate. Because of progressive clinical signs, electrolyte abnormalities, increased hepatic enzyme activity and bilirubin concentrations, and the development of pigmenturia, referral to specialist care was sought. On presentation, the dog was intermittently somnolent and then maniacal. Sinus tachycardia persisted, and hyperthermia was documented. Hospitalization for supportive care was undertaken, and the dog was administered IV fluids, flumazenil, antiepileptics, and IV lipid emulsion therapy. The dog developed hypoglycemia and treated with dextrose supplementation. Progressive increases in liver enzyme activities as well as pronounced increase in creatine kinase activity, consistent with rhabdomyolysis, were noted. Over the course of 48 hours, the hypoglycemia resolved, and clinical signs significantly improved. Ultimately, the dog was discharged with improved clinical signs, with the owner reporting that 1 week after discharge, a full recovery had been made, and no residual clinical signs persisted.
To the authors' knowledge, there are no previous reports of phenibut intoxication in small animals. The growing availability and use of this drug by people in the past several years highlight the need for a greater understanding of its effects in companion animals.
描述一只狗在摄入神经精神药物苯丁胺后成功治疗严重神经和心血管异常。
一只 2 岁去势雄性魏玛犬摄入约 1600mg/kg 的苯丁胺后，被发现无反应且侧卧在尿液中。在急诊就诊时，该犬表现出神经不适当、心动过速、高血压和呼吸频率显著降低。由于进行性临床症状、电解质异常、肝酶活性和胆红素浓度增加以及出现色素尿，因此寻求专科治疗。就诊时，该犬间歇性昏睡，然后出现躁狂。窦性心动过速持续存在，并记录到体温过高。住院接受支持性治疗，给予该犬静脉输液、氟马西尼、抗癫痫药和静脉内脂肪乳剂治疗。该犬出现低血糖并接受葡萄糖补充治疗。随着时间的推移，肝酶活性逐渐增加，肌酸激酶活性显著增加，符合横纹肌溶解症。在 48 小时内，低血糖得到解决，临床症状显著改善。最终，该犬出院时临床症状改善，主人报告称出院后 1 周，完全康复，没有残留的临床症状。
据作者所知，以前没有报道过小动物苯丁胺中毒。近年来，这种药物在人类中的应用越来越广泛，这凸显了人们需要更好地了解其在伴侣动物中的作用。
