Olofsson J, Bake B, Svärdsudd K, Skoogh B E
Eur J Respir Dis. 1986 Jul;69(1):46-56.
The single breath N2-test and spirometry were carried out on two occasions 7 years apart in 460 men, 50 and 60 years old and sampled from the general population. We analyzed the relationship between the rate of decline in FEV1 during the follow-up and the steepness of the slope of phase III at the start of the study. The results showed an association between an increased rate of decline in FEV1 during the follow-up period and a steep slope of phase III at the start of the study, allowing for age, smoking habits and FEV1 at the start of the study (p less than 0.001). An increase in the slope of phase III from e.g. 1.0 to 4.0% N2/l in moderate smokers was found to predict an increase in the rate of decline in FEV1 by 50%.
对从普通人群中抽取的460名年龄在50岁和60岁的男性，在相隔7年的两个时间点进行了单次呼吸氮气测试和肺活量测定。我们分析了随访期间第一秒用力呼气容积（FEV1）下降速率与研究开始时第三阶段斜率陡度之间的关系。结果显示，在考虑年龄、吸烟习惯和研究开始时的FEV1的情况下，随访期间FEV1下降速率增加与研究开始时第三阶段斜率陡峭有关（p<0.001）。发现在中度吸烟者中，第三阶段斜率从例如1.0%氮气/升增加到4.0%氮气/升，可预测FEV1下降速率增加50%。
