Vestbo J, Knudsen K M, Rasmussen F V
Medical Department P, Bispebjerg Hospital, Denmark.
Lung. 1990;168(2):93-101. doi: 10.1007/BF02719679.
The relationship between indices of the single-breath nitrogen test (SBNT) measured in 1974 and hospitalization in the 9 year period 1977-1986 was examined in a random population sample of 876 men aged 46-69 years. Men who could not perform acceptable SBNT tracings had an increased risk of hospitalization due to respiratory disease in general. When age and smoking habits were controlled for, slope of phase III was significantly related to hospitalization due to respiratory disease in general and chronic obstructive pulmonary disease (COPD), whereas closing volume and closing capacity were marginally related to hospitalization due to respiratory disease in general but not to hospitalization due to COPD. The relationship between slope of phase III and hospitalization due to COPD remained significant after the forced expiratory volume in 1 sec (FEV1) was controlled for: odds ratio 1.4 per % N2/L (95% confidence interval 1.1-1.7). The effect of the slope of phase III was considered to be clinically insignificant, and we conclude that in a random population sample indices from only 1 SBNT do not provide prognostic information concerning hospitalization in addition to that provided by FEV1.
在一个由876名年龄在46至69岁之间的男性组成的随机人群样本中，研究了1974年测量的单次呼吸氮试验（SBNT）指标与1977年至1986年9年期间住院情况之间的关系。一般来说，那些无法进行可接受的SBNT描记图的男性因呼吸系统疾病住院的风险增加。在对年龄和吸烟习惯进行控制后，III期斜率与一般呼吸系统疾病和慢性阻塞性肺疾病（COPD）导致的住院显著相关，而闭合容积和闭合容量与一般呼吸系统疾病导致的住院仅有微弱关联，但与COPD导致的住院无关。在对1秒用力呼气量（FEV₁）进行控制后，III期斜率与COPD导致的住院之间的关系仍然显著：比值比为每%N₂/L 1.4（95%置信区间1.1 - 1.7）。III期斜率的影响被认为在临床上无显著意义，并且我们得出结论，在一个随机人群样本中，仅一次SBNT的指标除了FEV₁所提供的信息外，并未提供关于住院的预后信息。
