Gruenthal M, Armstrong D R, Ault B, Nadler J V
Exp Neurol. 1986 Sep;93(3):621-30. doi: 10.1016/0014-4886(86)90181-0.
Intracerebroventricular kainic acid produces in rats brain lesions similar to Ammon's horn sclerosis in humans. To test the hypothesis that these lesions result indirectly from prolonged seizure activity and not from a direct action of kainic acid on the neurons that are destroyed, the effects of intracerebroventricular kainic acid and bicuculline methiodide were compared. Although bicuculline methiodide seizures differed dramatically from kainic acid seizures, both electrographically and behaviorally, the resulting brain lesions were similar for a given total limbic seizure duration. These results, in combination with other data, support the view that lesions made by intracerebroventricular administration of convulsants are indeed caused by prolonged limbic seizures. The total duration of seizure activity appears to be one important variable.
脑室内注射海藻酸可在大鼠脑内产生类似于人类海马硬化的病变。为了验证这些病变是由长时间癫痫活动间接导致而非海藻酸对被破坏神经元的直接作用这一假说，对脑室内注射海藻酸和甲磺酸荷包牡丹碱的效果进行了比较。尽管甲磺酸荷包牡丹碱诱发的癫痫在脑电图和行为表现上与海藻酸诱发的癫痫有显著差异，但对于给定的总边缘叶癫痫持续时间，二者导致的脑损伤相似。这些结果与其他数据相结合，支持了以下观点：脑室内注射惊厥剂所造成的损伤确实是由长时间的边缘叶癫痫引起的。癫痫活动的总持续时间似乎是一个重要变量。
