Czuczwar S J, Turski L, Turski W, Kleinrok Z
Methods Find Exp Clin Pharmacol. 1982;4(5):293-8.
Rats were injected uni- or bilaterally with intracerebroventricular kainic acid (0.1 micrograms per one ventricle in a volume of 5 microliters) and the animals were subsequently challenged with penetetrazol (PTZ) on the 21st day after the administration of the neurotoxin. PTZ was given either subcutaneously in a single dose of 70 mg/kg or intraperitoneally, one injection every 48 hours for a total of 15 trials, in doses of 20 mg/kg to induce kindled seizures. It was found that kainic acid-lesioned animals (especially those injected bilaterally) were more sensitive to the convulsant action of PTZ both in acute and kindled convulsions. The disruption of the hippocampal pyramidal projection to the septum may be responsible for these effects.
给大鼠单侧或双侧脑室内注射 kainic 酸（每侧脑室 0.1 微克，体积为 5 微升），随后在给予神经毒素后的第 21 天用戊四氮（PTZ）对动物进行激发试验。PTZ 以 70 mg/kg 的单剂量皮下注射，或每 48 小时腹腔注射一次，共 15 次试验，剂量为 20 mg/kg 以诱导点燃性癫痫发作。发现 kainic 酸损伤的动物（尤其是双侧注射的动物）在急性和点燃性惊厥中对 PTZ 的惊厥作用更敏感。海马锥体细胞向隔区投射的破坏可能是这些效应的原因。
