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Icenticaftor, Novel Therapy for COPD: This Glass Is Half Full.

作者信息

Rennard Stephen I

机构信息

Department of Internal Medicine University of Nebraska Medical Center Omaha, Nebraska.

出版信息

Am J Respir Crit Care Med. 2023 Aug 15;208(4):346-348. doi: 10.1164/rccm.202307-1175ED.

DOI:10.1164/rccm.202307-1175ED
PMID:37437299
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10449066/
Abstract
摘要

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Reply to Gan .回复甘。
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Am J Respir Crit Care Med. 2023 Aug 15;208(4):417-427. doi: 10.1164/rccm.202303-0458OC.
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Companion diagnostic requirements for spatial biology using multiplex immunofluorescence and multispectral imaging.使用多重免疫荧光和多光谱成像进行空间生物学研究的伴随诊断要求。
Front Mol Biosci. 2023 Feb 9;10:1051491. doi: 10.3389/fmolb.2023.1051491. eCollection 2023.
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Clinical utility of liquid biopsy-based companion diagnostics in the non-small-cell lung cancer treatment.基于液体活检的伴随诊断在非小细胞肺癌治疗中的临床应用
Explor Target Antitumor Ther. 2022;3(5):630-642. doi: 10.37349/etat.2022.00104. Epub 2022 Oct 31.
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Molecular Biomarkers of Response to Cancer Immunotherapy.癌症免疫治疗反应的分子生物标志物。
Clin Lab Med. 2022 Sep;42(3):469-484. doi: 10.1016/j.cll.2022.05.004. Epub 2022 Aug 22.
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Cystic Fibrosis Transmembrane Conductance Regulator: Roles in Chronic Obstructive Pulmonary Disease.囊性纤维化跨膜电导调节因子：在慢性阻塞性肺疾病中的作用。
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6
Dysfunction in the Cystic Fibrosis Transmembrane Regulator in Chronic Obstructive Pulmonary Disease as a Potential Target for Personalised Medicine.慢性阻塞性肺疾病中囊性纤维化跨膜调节因子功能障碍作为个性化医疗的潜在靶点
Biomedicines. 2021 Oct 10;9(10):1437. doi: 10.3390/biomedicines9101437.
7
Discovery of Icenticaftor (QBW251), a Cystic Fibrosis Transmembrane Conductance Regulator Potentiator with Clinical Efficacy in Cystic Fibrosis and Chronic Obstructive Pulmonary Disease.Icenticaftor（QBW251）的发现，一种囊性纤维化跨膜电导调节剂增强剂，在囊性纤维化和慢性阻塞性肺疾病中具有临床疗效。
J Med Chem. 2021 Jun 10;64(11):7241-7260. doi: 10.1021/acs.jmedchem.1c00343. Epub 2021 May 24.
8
Efficacy and Safety of the CFTR Potentiator Icenticaftor (QBW251) in COPD: Results from a Phase 2 Randomized Trial.ICENTICAFTOR（QBW251）在 COPD 中的疗效和安全性：一项 2 期随机试验的结果。
Int J Chron Obstruct Pulmon Dis. 2020 Oct 5;15:2399-2409. doi: 10.2147/COPD.S257474. eCollection 2020.
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Cystic Fibrosis: Emergence of Highly Effective Targeted Therapeutics and Potential Clinical Implications.囊性纤维化：高效靶向治疗药物的出现及其潜在的临床意义。
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Eur Respir Rev. 2018 Aug 1;27(149). doi: 10.1183/16000617.0022-2018. Print 2018 Sep 30.