Department of Pathology, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, China; Department of Pathology, School of Basic Medical Sciences, Southern Medical University, Guangzhou, Guangdong, China; State Key Laboratory of Oncology in Southern China, Department of Experimental, Guangzhou, Guangdong, China.
Cytokine. 2023 Sep;169:156292. doi: 10.1016/j.cyto.2023.156292. Epub 2023 Jul 10.
C-C motif chemokine receptor 2 (CCR2), together with its ligands, especially C-C motif ligand 2 (CCL2), to which CCR2 has the highest affinity, form a noteworthy signaling pathway in recruiting macrophages for the immune responses among variegated disorders in vivo environment. Scientometric methods are used to analyze intestine-related CCR2 expression. We describe the current knowledge on biological function of CCR2 in physiological intestine in three dimensions, namely its effects on stromal cells, angiogenesis, and remodeling. However, anomalous expression of CCR2 has also been conveyed to correlate with detrimental outcomes in intestine, such as infective colitis, inflammatory bowel disease, carcinogenesis, and colon-related metastasis. In this article, we briefly summarize recent experimental works on CCR2 and its ligands, mostly CCL2, in intestinal-related physiological and pathological states to ravel out their working mechanisms in intestinal diseases.
C-C 基序趋化因子受体 2（CCR2）与其配体，特别是对其具有最高亲和力的 C-C 基序配体 2（CCL2），在招募巨噬细胞以应对体内环境中各种疾病的免疫反应中形成了一条重要的信号通路。科学计量学方法用于分析与肠道相关的 CCR2 表达。我们从三个方面描述了 CCR2 在生理肠道中的生物学功能的现有知识，即其对基质细胞、血管生成和重塑的影响。然而，CCR2 的异常表达也与肠道中的不良后果相关，如感染性结肠炎、炎症性肠病、癌变和与结肠相关的转移。在本文中，我们简要总结了最近关于 CCR2 及其配体（主要是 CCL2）在与肠道相关的生理和病理状态下的实验工作，以揭示它们在肠道疾病中的作用机制。
