白细胞介素-3 在大脑中安家。
IL-3 finds its home in the brain.
机构信息
Department of Cancer Immunology and Virology, Dana-Farber Cancer Institute, Boston, MA, USA; Department of Immunology, Harvard Medical School, Boston, MA, USA.
Department of Cancer Immunology and Virology, Dana-Farber Cancer Institute, Boston, MA, USA; Department of Immunology, Harvard Medical School, Boston, MA, USA.
出版信息
Immunity. 2023 Jul 11;56(7):1431-1433. doi: 10.1016/j.immuni.2023.06.009.
Interleukin-3 (IL-3) induces emergency hematopoiesis in settings of acute inflammation. In this issue of Immunity, Kiss et al. find that IL-3 derived from astrocytes and CD4 T cells is a key regulatory cytokine of the central nervous system, and increased IL-3 signaling exacerbates neuroinflammation.
白细胞介素-3（IL-3）可在急性炎症情况下诱导紧急造血。在本期《免疫》中，Kiss 等人发现，星形胶质细胞和 CD4 T 细胞产生的 IL-3 是中枢神经系统的关键调节细胞因子，增加 IL-3 信号会加剧神经炎症。
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