禁食和热量限制的性别和时间特异性效应。

Sex- and timing-specific effects of fasting and caloric restriction.

机构信息

Institute of Molecular Biosciences, NAWI Graz, University of Graz, Graz, Austria; Field of Excellence BioHealth, University of Graz, Graz, Austria; BioTechMed Graz, Graz, Austria.

出版信息

Cell Metab. 2023 Jul 11;35(7):1091-1093. doi: 10.1016/j.cmet.2023.06.001.

DOI:10.1016/j.cmet.2023.06.001

PMID:37437541

Abstract

Optimizing food quantity and fasting time may improve health and lifespan. We summarize emerging knowledge on sex, age, and circadian timing as important determinants for the efficacy of dietary interventions and highlight results from Duregon et al. pointing to a favorable combination of caloric restriction (CR) and fasting in aged female mice.

摘要

优化食物摄入量和禁食时间可能有助于改善健康和延长寿命。我们总结了关于性别、年龄和昼夜节律时间的新出现的知识，这些因素是饮食干预效果的重要决定因素，并强调了 Duregon 等人的研究结果，表明在老年雌性小鼠中，热量限制（CR）和禁食的组合是有利的。