Institute for Scintillation Materials, National Academy of Sciences of Ukraine, 60 Nauky Ave, Kharkiv, 61072, Ukraine.
SSI, Institute for Single Crystal, National Academy of Sciences of Ukraine, 60 Nauky Ave, Kharkiv, 61072, Ukraine.
Biogerontology. 2024 Nov 25;26(1):14. doi: 10.1007/s10522-024-10156-0.
GdVO:Eu nanoparticles (OVNPs) have previously been shown to exhibit anti-aging effects in old rats.The accelerated aging model (overnutrition in early postnatal ontogenesis (POF)) was used to confirm the effect of OVNPs as a potential geroprotector. A comparative study of the effect of OVNPs, calorierestriction (CR) and CR-mimetic-metformin was carried out using a number of criteria: survival, prooxidant-antioxidant balance in the liver and blood, physiological parameters of male Wistar rats with accelerated aging. It was found that the survival of rats with POF was lower than that of control animals.It was found that the rate of superoxide radical formation and the content of lipid hydroperoxides in the mitochondria and microsomes of the liver and blood serum of rats with POF were higher, and the activities of glutathione peroxidases and the GSH content were significantly lower than in the control animals.It was also found that POF leads to perturbation of physiological parameters (body weight, liver weight, liver mass coefficient, body temperature and blood thyroxine concentration) characterizing the quality of life. Long-term use of OVNPs, CR or metformin in rats with accelerated aging normalized the imbalance of the prooxidant-antioxidant system, improved the physiological parameters, and increased the survival of these experimental animals. Moreover, the increase in survival was most pronounced with the use of CR and OVNPs. Considering our results andthe inadmissibility of long-term use of CR, it should be concluded that GdVO:Eu nanoparticles are promising for the development of agents that slow down the accelerated aging of an organism.
GdVO:Eu 纳米颗粒（OVNPs）先前已被证明在老年大鼠中具有抗衰老作用。使用加速老化模型（早期产后发生期（POF）的过度营养）来确认 OVNPs 作为潜在的抗衰老保护剂的效果。通过使用多种标准，对 OVNPs、热量限制（CR）和 CR 模拟物二甲双胍的效果进行了比较研究：雄性 Wistar 大鼠加速老化的存活、肝脏和血液中的促氧化剂-抗氧化剂平衡、生理参数。结果发现，POF 大鼠的存活率低于对照动物。结果发现，POF 大鼠肝脏和血液血清中线粒体和微粒体中超氧自由基形成率和脂质过氧化物含量较高，谷胱甘肽过氧化物酶活性和 GSH 含量明显低于对照动物。还发现，POF 导致生理参数（体重、肝重、肝质量系数、体温和血液甲状腺素浓度）发生变化，这些参数是生活质量的特征。在加速老化的大鼠中长期使用 OVNPs、CR 或二甲双胍可使促氧化剂-抗氧化剂系统失衡正常化，改善生理参数，并提高这些实验动物的存活率。此外，使用 CR 和 OVNPs 可最大程度地提高存活率。考虑到我们的结果和长期使用 CR 的不可行性，应该得出结论，GdVO:Eu 纳米颗粒是开发减缓生物体加速老化的药物的有前途的候选物。
