Nishiguchi S, Otani S, Matsui-Yuasa I, Morisawa S, Monna T, Kuroki T, Kobayashi K, Yamamoto S
FEBS Lett. 1986 Sep 1;205(1):61-5. doi: 10.1016/0014-5793(86)80866-3.
Mouse interferon (alpha + beta) given to mice by intraperitoneal injection suppressed both the accumulation of putrescine and stimulation of DNA synthesis in liver caused by partial hepatectomy. The suppression of DNA synthesis was completely reversed by exogenous putrescine. The same results were obtained when core 2',5'-oligoadenylate instead of interferon was given to partially hepatectomized mice. These results suggest that interferon inhibits putrescine formation through elevating the 2',5'-oligoadenylate level and thus inhibits DNA synthesis in the regenerating liver.
通过腹腔注射给予小鼠的小鼠干扰素（α+β）抑制了部分肝切除引起的肝脏中腐胺积累和DNA合成的刺激。外源性腐胺完全逆转了DNA合成的抑制。当给部分肝切除的小鼠注射核心2'，5'-寡腺苷酸而不是干扰素时，也得到了相同的结果。这些结果表明，干扰素通过提高2'，5'-寡腺苷酸水平抑制腐胺形成，从而抑制再生肝脏中的DNA合成。
