抑制再生大鼠肝脏中的多胺积累和脱氧核糖核酸合成。
Inhibition of polyamine accumulation and deoxyribonucleic acid synthesis in regenerating rat liver.
作者信息
Pösö H, Jänne J
出版信息
Biochem J. 1976 Aug 15;158(2):485-8. doi: 10.1042/bj1580485.
Abstract
Repeated injections of 1,3-diaminopropane into rats after partial hepatectomy caused a repression-type inhibiton of liver ornithine decarboxylase (EC 4.1.1.17) and totally prevented the marked increases in liver putrescine and spermidine concentrations that normally occur in response to partial hepatectomy. The inhibition of polyamine synthesis by diaminopropane was accompanied by a profound decrease (about 80%) in the synthesis of DNA in the regenerating rat liver without any changes in the synthesis of RNA and total liver protein.
摘要
在大鼠部分肝切除术后反复注射1,3 -二氨基丙烷，会导致肝脏鸟氨酸脱羧酶（EC 4.1.1.17）受到阻遏型抑制，并完全阻止了肝脏中腐胺和亚精胺浓度通常因部分肝切除而出现的显著升高。二氨基丙烷对多胺合成的抑制伴随着再生大鼠肝脏中DNA合成的大幅下降（约80%），而RNA合成和肝脏总蛋白合成则没有任何变化。
相似文献
1
Inhibition of polyamine accumulation and deoxyribonucleic acid synthesis in regenerating rat liver.抑制再生大鼠肝脏中的多胺积累和脱氧核糖核酸合成。
Biochem J. 1976 Aug 15;158(2):485-8. doi: 10.1042/bj1580485.
2
Specific inhibition of the synthesis of putrescine and spermidine by 1,3-diaminopropane in rat liver in vivo.1,3 -二氨基丙烷对大鼠肝脏体内腐胺和亚精胺合成的特异性抑制作用
Biochim Biophys Acta. 1977 Mar 29;497(1):288-97. doi: 10.1016/0304-4165(77)90162-3.
3
Effects of inhibitors of S-adenosylmethionine decarboxylase and ornithine decarboxylase on DNA synthesis in rat liver after partial hepatectomy.S-腺苷甲硫氨酸脱羧酶和鸟氨酸脱羧酶抑制剂对大鼠部分肝切除术后肝脏DNA合成的影响。
Biochim Biophys Acta. 1978 Jan 26;517(1):169-80. doi: 10.1016/0005-2787(78)90044-8.
4
Inhibition of increases in ornithine decarboxylase and putrescine has no effect on rat liver regeneration.抑制鸟氨酸脱羧酶和腐胺的增加对大鼠肝脏再生没有影响。
Am J Physiol. 1992 Apr;262(4 Pt 1):G677-84. doi: 10.1152/ajpgi.1992.262.4.G677.
5
Compensatory route of spermidine acetylation and oxidation can supply sufficient putrescine for hepatic DNA synthesis at an early stage after partial hepatectomy in diaminopropane-treated rats.在经二氨基丙烷处理的大鼠部分肝切除术后早期，亚精胺乙酰化和氧化的代偿途径可为肝脏DNA合成提供足够的腐胺。
J Biochem. 1988 Jul;104(1):98-101. doi: 10.1093/oxfordjournals.jbchem.a122431.
6
Inhibition of ornithine decarboxylase activity and spermidine accumulation in regenerating rat liver.鸟氨酸脱羧酶活性的抑制及再生大鼠肝脏中精胺的积累
Biochem Biophys Res Commun. 1976 Apr 19;69(4):885-92. doi: 10.1016/0006-291x(76)90456-3.
7
Calmodulin antagonist trifluoperazine inhibits polyamine biosynthesis and liver regeneration.钙调蛋白拮抗剂三氟拉嗪抑制多胺生物合成和肝脏再生。
Br J Surg. 1988 Dec;75(12):1160-2. doi: 10.1002/bjs.1800751205.
8
Inhibition of polyamine accumulation and cell proliferation by derivatives of diaminopropane in Ehrlich ascites cells grown in culture.在培养的艾氏腹水癌细胞中，二氨基丙烷衍生物对多胺积累和细胞增殖的抑制作用。
Biochim Biophys Acta. 1979 Oct 25;564(3):473-87. doi: 10.1016/0005-2787(79)90037-6.
9
Synthesis and accumulation of polyamines in rat liver regenerating after treatment with carbon tetrachloride.四氯化碳处理后大鼠肝脏再生过程中多胺的合成与积累。
Biochem Biophys Res Commun. 1973 Sep 5;54(1):350-7. doi: 10.1016/0006-291x(73)90929-7.
10
Supplemental putrescine reverses ethanol-associated inhibition of liver regeneration.补充腐胺可逆转乙醇相关的肝再生抑制。
Hepatology. 1990 Oct;12(4 Pt 1):633-7. doi: 10.1002/hep.1840120402.
引用本文的文献
1
Putrescine treatment reverses α-tocopherol-induced desynchronization of polyamine and retinoid metabolism during rat liver regeneration.腐胺处理可逆转α-生育酚诱导的大鼠肝脏再生过程中多胺和类视黄醇代谢的不同步现象。
J Transl Med. 2016 Oct 26;14(1):307. doi: 10.1186/s12967-016-1062-y.
2
Effects of exogenous 1,3-diaminopropane and spermidine on senescence of oat leaves : I. Inhibition of protease activity, ethylene production, and chlorophyll loss as related to polyamine content.外源1,3 - 二氨基丙烷和亚精胺对燕麦叶片衰老的影响：I. 与多胺含量相关的蛋白酶活性、乙烯生成及叶绿素损失的抑制作用
Plant Physiol. 1982 Dec;70(6):1592-6. doi: 10.1104/pp.70.6.1592.
3
The role of polyamines in liver regeneration after hepatectomy with ischemic injury.多胺在肝切除术后伴有缺血性损伤的肝再生中的作用。
Surg Today. 1997;27(9):833-9. doi: 10.1007/BF02385274.
4
Reversible inhibition of bacterial growth after specific inhibition of spermidine synthase by dicyclohexylamine.二环己胺特异性抑制亚精胺合酶后细菌生长的可逆抑制
Biochem J. 1984 Nov 1;223(3):823-30. doi: 10.1042/bj2230823.
5
Antitumor effect of methylglyoxal bis(3-aminopropylamidinohydrazone), a new inhibitor of S-adenosylmethionine and ornithine decarboxylases, on human erythroid leukemia K562 cells.新型S-腺苷甲硫氨酸和鸟氨酸脱羧酶抑制剂双（3-氨丙基脒腙）甲基乙二醛对人红白血病K562细胞的抗肿瘤作用
Cancer Chemother Pharmacol. 1988;22(3):187-90. doi: 10.1007/BF00273408.
6
Polyamines and their biosynthetic enzymes in Ehrlich ascites-carcinoma cells. Modification of tumour polyamine pattern by diamines.艾氏腹水癌细胞中的多胺及其生物合成酶。二胺对肿瘤多胺模式的改变。
Biochem J. 1977 Jul 15;166(1):89-94. doi: 10.1042/bj1660089.
7
Role of pyridoxal phosphate in mammalian polyamine biosynthesis. Lack of requirement for mammalian S-adenosylmethionine decarboxylase activity.磷酸吡哆醛在哺乳动物多胺生物合成中的作用。对哺乳动物S-腺苷甲硫氨酸脱羧酶活性的需求缺失。
Biochem J. 1977 Jul 15;166(1):81-8. doi: 10.1042/bj1660081.
8
Effects of aliphatic diamines on rat liver ornithine decarboxylase activity.脂肪族二胺对大鼠肝脏鸟氨酸脱羧酶活性的影响。
Biochem J. 1978 Mar 15;170(3):651-60. doi: 10.1042/bj1700651.
9
Ornithine decarboxylase activity and the onset of deoxyribonucleic acid synthesis in regenerating liver.再生肝中鸟氨酸脱羧酶活性与脱氧核糖核酸合成的起始
Biochem J. 1978 Jan 15;170(1):123-7. doi: 10.1042/bj1700123.
10
Ornithine decarboxylase and polyamines in liver and kidneys of rats on cyclical regimen of protein-free and protein-containing diets. Relationship to deoxyribonucleic acid synthesis in liver.采用无蛋白饮食和含蛋白饮食周期性方案的大鼠肝脏和肾脏中的鸟氨酸脱羧酶和多胺。与肝脏中脱氧核糖核酸合成的关系。
Biochem J. 1977 Oct 15;168(1):49-56. doi: 10.1042/bj1680049.
本文引用的文献
1
Protein measurement with the Folin phenol reagent.使用福林酚试剂进行蛋白质测定。
J Biol Chem. 1951 Nov;193(1):265-75.
2
STUDIES ON THE DETERMINATION OF SPERMIDINE AND SPERMINE AND THEIR METABOLISM IN THE DEVELOPING CHICK EMBRYO.发育中鸡胚中亚精胺和精胺的测定及其代谢研究。
Acta Physiol Scand Suppl. 1963:SUPPL 218:1-81.
3
Effect of inhibition of spermidine formation on protein and nucleic acid synthesis during lymphocyte activation.抑制亚精胺形成对淋巴细胞激活过程中蛋白质和核酸合成的影响。
FEBS Lett. 1973 Feb 1;29(3):301-304. doi: 10.1016/0014-5793(73)80044-4.
4
Stimulation of polyamine synthesis in relation to nucleic acids in regenerating rat liver.再生大鼠肝脏中多胺合成与核酸的关系研究
Biochim Biophys Acta. 1966 Jul 20;123(1):197-201. doi: 10.1016/0005-2787(66)90173-0.
5
Amine synthesis in regenerating rat liver: extremely rapid turnover of ornithine decarboxylase.再生大鼠肝脏中的胺合成：鸟氨酸脱羧酶的极高周转率。
Mol Pharmacol. 1969 May;5(3):253-62.
6
Stimulation of spermidine synthesis in the regenerating rat liver: relation to increased ornithine decarboxylase activity.再生大鼠肝脏中精胺合成的刺激：与鸟氨酸脱羧酶活性增加的关系。
Acta Chem Scand. 1968;22(4):1349-51. doi: 10.3891/acta.chem.scand.22-1349.
7
Mechanism of stimulation of polyamine synthesis by growth hormone in rat liver.生长激素刺激大鼠肝脏多胺合成的机制。
Biochim Biophys Acta. 1968 Sep 24;166(2):419-26. doi: 10.1016/0005-2787(68)90230-x.
8
On the purification of L-ornithine decarboxylase from rat prostate and effects of thiol compounds on the enzyme.大鼠前列腺L-鸟氨酸脱羧酶的纯化及硫醇化合物对该酶的影响
J Biol Chem. 1971 Mar 25;246(6):1725-32.
9
10
Polyamines and RNA synthesis in a polyauxotrophic strain of E. coli.大肠杆菌多营养缺陷型菌株中的多胺与RNA合成
Proc Natl Acad Sci U S A. 1966 Jun;55(6):1587-93. doi: 10.1073/pnas.55.6.1587.
Zotero 插件