Persson L, Holm I, Heby O
FEBS Lett. 1986 Sep 15;205(2):175-8. doi: 10.1016/0014-5793(86)80892-4.
The activity of ornithine decarboxylase (ODC), the first and rate-limiting enzyme in the polyamine biosynthetic pathway, is dramatically increased in proliferating cells. In addition to transcriptional regulation of ODC, the present study shows that the enzyme is regulated at the translational level by putrescine and spermidine. ODC synthesis is inhibited by an increase and stimulated by a decrease in their cellular content. Spermidine is a more potent negative regulator than is putrescine. The effects of polyamines on ODC synthesis were not attributable to changes in the cellular content of ODC mRNA, thus demonstrating regulation at the translational level.
鸟氨酸脱羧酶（ODC）是多胺生物合成途径中的首个限速酶，其活性在增殖细胞中显著增加。除了ODC的转录调控外，本研究表明该酶在翻译水平上受腐胺和亚精胺的调节。ODC的合成受到其细胞内含量增加的抑制，而受到其细胞内含量减少的刺激。亚精胺是比腐胺更有效的负调节因子。多胺对ODC合成的影响并非归因于ODC mRNA细胞内含量的变化，从而证明了在翻译水平上的调节。
