Abu Dhabi Stem Cells Center (ADSCC), Villa 25, Al Misahah St., Rowdhat, PO Box 4600, Abu Dhabi, United Arab Emirates.
Abu Dhabi Stem Cells Center (ADSCC), Villa 25, Al Misahah St., Rowdhat, PO Box 4600, Abu Dhabi, United Arab Emirates.
Transfus Apher Sci. 2023 Oct;62(5):103758. doi: 10.1016/j.transci.2023.103758. Epub 2023 Jul 5.
Significant advances in procedural information displayed by current apheresis machines have been made, but analyses of cell collection efficiency (CE) still rely on calculations done by apheresis professionals. Accordingly, understanding CE equations can support the optimization of apheresis techniques and identification of incidents that could impact the procedure's effectiveness. This report summarizes classical and novel CE analyses applied to apheresis exemplified by an actual case of hematopoietic progenitor cell collection. In addition to the apheresis yield and most common CE and CE formulas, we present the instantaneous and corrected CE, fold enrichment, collection throughput, collection rate and its variants, average inlet rate, classical and adjusted captured cells, recruitment pool, recruitment factor, recruitment coefficient, blood component loss, predictive apheresis yield, and performance ratio calculations. Moreover, the mathematical relationship between these CE equations is also shown, which can be helpful in many apheresis procedures.
目前，在单采机显示的程序信息方面取得了重大进展，但细胞采集效率 (CE) 的分析仍依赖于单采专业人员的计算。因此，了解 CE 方程可以支持优化单采技术和识别可能影响程序效果的事件。本报告总结了应用于单采的经典和新型 CE 分析，并用造血祖细胞采集的实际案例进行了举例说明。除了单采产量和最常见的 CE 和 CE 公式外，我们还介绍了瞬时和校正的 CE、倍增值、采集通量、采集速率及其变体、平均入口速率、经典和调整后的捕获细胞、募集池、募集因子、募集系数、血液成分损失、预测单采产量和性能比计算。此外，还展示了这些 CE 方程之间的数学关系，这在许多单采过程中可能会有所帮助。
