Jenkins S A, Baxter J N, Devitt P, Taylor I, Shields R
Digestion. 1986;34(4):236-42. doi: 10.1159/000199336.
The effects of varying rates of alcohol infusion (0.015-0.12 mg/g body weight/min) on hepatic haemodynamics were studied in male Wistar rats. An infusion of 0.015 mg/g body weight/min alcohol had no significant effect on portal pressure (PP) or wedged hepatic venous pressure (WHVP). However, increasing rates of infusion of alcohol (0.03-0.12 mg/g body weight/min) progressively increased PP and WHVP, the maximum increase in PP occurring following an infusion of 0.12 mg/g body weight/min (6.5 +/- 0.5 - 10.3 +/- 0.6 mm Hg). The effect of varying rates of alcohol infusion on portal venous flow and liver blood flow was biphasic. Thus following an infusion of 0.03 mg/g body weight/min alcohol, liver blood flow (40.6 +/- 4.9 - 54.3 +/- 5.8 ml/100 g/min) and portal venous flow (28.6 +/- 2.9 - 41.3 +/- 4.1 ml/min) were increased. However, following infusions of 0.06 and 0.12 mg/g body weight/min alcohol, liver blood flow and portal venous flow were decreased. The results suggest that previous conflicting reports on the effects of alcohol on hepatic haemodynamics may be related to the dose of alcohol administered.
在雄性Wistar大鼠中研究了不同酒精输注速率（0.015 - 0.12毫克/克体重/分钟）对肝脏血流动力学的影响。以0.015毫克/克体重/分钟的速率输注酒精对门静脉压力（PP）或肝静脉楔压（WHVP）没有显著影响。然而，酒精输注速率增加（0.03 - 0.12毫克/克体重/分钟）会使PP和WHVP逐渐升高，在以0.12毫克/克体重/分钟的速率输注后PP出现最大升高（从6.5±0.5毫米汞柱升至10.3±0.6毫米汞柱）。不同酒精输注速率对门静脉血流和肝脏血流的影响是双相的。因此，在以0.03毫克/克体重/分钟的速率输注酒精后，肝脏血流（从40.6±4.9毫升/100克/分钟增至54.3±5.8毫升/100克/分钟）和门静脉血流（从28.6±2.9毫升/分钟增至41.3±4.1毫升/分钟）增加。然而，在以0.06和0.12毫克/克体重/分钟的速率输注酒精后，肝脏血流和门静脉血流减少。结果表明，先前关于酒精对肝脏血流动力学影响的相互矛盾的报告可能与所给予的酒精剂量有关。
