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Co-stimulatory and immune checkpoint molecules are important in the tumor microenvironment of Hodgkin-like adult T-cell leukemia/lymphoma.

作者信息

Takeuchi Mai, Miyoshi Hiroaki, Semba Yuichiro, Yamada Kyohei, Nakashima Kazutaka, Sato Kensaku, Furuta Takuya, Moritsubo Mayuko, Ogura Yusuke, Tanaka Ken, Imamoto Teppei, Arakawa Fumiko, Kohno Kei, Ohshima Koichi

机构信息

Department of Pathology, Kurume University School of Medicine, Kurume city, Fukuoka.

Department of Medicine and Biosystemic Science, Kyusyu University Faculty of Medicine, Fukuoka city, Fukuoka.

出版信息

Haematologica. 2023 Dec 1;108(12):3496-3501. doi: 10.3324/haematol.2023.283163.

DOI:10.3324/haematol.2023.283163
PMID:37439334
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10690911/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/199e/10690911/74a482e49b49/1083496.fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/199e/10690911/3a03aa419b6c/1083496.fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/199e/10690911/74a482e49b49/1083496.fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/199e/10690911/3a03aa419b6c/1083496.fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/199e/10690911/74a482e49b49/1083496.fig2.jpg

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Molecular biology of Hodgkin lymphoma.霍奇金淋巴瘤的分子生物学。
Leukemia. 2021 Apr;35(4):968-981. doi: 10.1038/s41375-021-01204-6. Epub 2021 Mar 8.
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Blood Adv. 2021 Jan 12;5(1):198-206. doi: 10.1182/bloodadvances.2020003201.
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First-in-human study of the safety, tolerability, pharmacokinetics, and pharmacodynamics of ALPN-101, a dual CD28/ICOS antagonist, in healthy adult subjects.ALPN-101，一种双重 CD28/ICOS 拮抗剂，在健康成年受试者中的安全性、耐受性、药代动力学和药效学的首次人体研究。
Clin Transl Sci. 2021 Jul;14(4):1314-1326. doi: 10.1111/cts.12983. Epub 2021 Mar 2.
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Clinical significance of CD28 gene-related activating alterations in adult T-cell leukaemia/lymphoma.成人 T 细胞白血病/淋巴瘤中 CD28 基因相关激活改变的临床意义。
Br J Haematol. 2021 Jan;192(2):281-291. doi: 10.1111/bjh.17211. Epub 2020 Nov 18.
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