Ohtani O, Ohtsuka A, Owen R L
Gastroenterology. 1986 Oct;91(4):947-55. doi: 10.1016/0016-5085(86)90699-2.
The three-dimensional organization of the lymphatics in the rabbit appendix was demonstrated by scanning electron microscopy of lymphatic corrosion casts and intact tissues. In the glandular mucosa a polygonal network of lymphatics led into perpendicularly oriented lymphatics continuous with the lymphatics in the thymus-dependent area. In the thymus-dependent area a plexus consisting of anastomosing tubular lymphatics led into the upper ends of the perifollicular sinuses. Each follicle was surrounded by a well-developed perifollicular sinus. From the bottoms of the sinuses thin lymphatics descended into the submucosal lymphatics. The cast of submucosal lymphatics showed notches corresponding to the locations of bicuspid valves. Lymphocytes migrating through the lymphatics and high-endothelial venules were only observed in the thymus-dependent area. The results indicate that the potential capacity of the perifollicular sinuses as a reservoir and as a drainage route for fluid and lymphocytes is great, but that the lymphatics in the thymus-dependent area are sites for lymphocyte migration from the follicles into the lymphatics. The well-developed lymphatic network in the glandular layer suggests great participation in fluid flux.
通过淋巴管铸型扫描电子显微镜和完整组织观察，展示了兔阑尾淋巴管的三维结构。在腺性黏膜中，多边形淋巴管网络通向与胸腺依赖区淋巴管相连的垂直定向淋巴管。在胸腺依赖区，由相互吻合的管状淋巴管组成的丛状结构通向滤泡周围窦的上端。每个滤泡都被发育良好的滤泡周围窦包围。从窦的底部，细小的淋巴管向下延伸至黏膜下淋巴管。黏膜下淋巴管铸型显示出与二尖瓣位置相对应的切迹。仅在胸腺依赖区观察到淋巴细胞通过淋巴管和高内皮微静脉迁移。结果表明，滤泡周围窦作为液体和淋巴细胞的储存库及引流途径的潜在能力很大，但胸腺依赖区的淋巴管是淋巴细胞从滤泡迁移至淋巴管的部位。腺层中发育良好的淋巴网络表明其在液体流动中发挥着重要作用。
