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[子宫下段肌层内注射tocolysis药物对后续全身麻醉下行剖宫产产妇心血管参数的影响]

[Effect of subpartal tocolysis on maternal cardiovascular parameters with subsequent cesarean section in general anesthesia].

作者信息

Pohl R, Wiest W, Hartung H J, Becker J

出版信息

Geburtshilfe Frauenheilkd. 1986 Jun;46(6):348-52. doi: 10.1055/s-2008-1035929.

Abstract

The influence of subpartal beta-sympathicomimetic tocolysis on a subsequent Caesarean section with halothane as inhalational anaesthetic was examined in 42 pregnant women. Alterations in the heart rate, blood pressure and heart action during the operation were measured. 23 patients (group "bolus") received fenoterol monotherapy. In 19 patients (group "iv-tocolysis") fenoterol was combined with the cardioselective beta-1-blocking agent metoprolol. In comparison with these two groups, 25 pregnant women without tocolysis were examined as controls. There were only slight differences in heart rate and blood pressure between the three groups. Arrhythmias were registered in 42 percent of the cases, in most cases during light anaesthesia before delivery. Sinus tachycardias with a heart rate of 130 beats per minute or more were observed most frequently. Arrhythmias of ectopic origin and sinus bradycardias, however, were found seldom. The incidence of arrhythmias in the three groups during Caesarean section did not differ significantly. There was no evidence for an increased occurrence of arrhythmias following beta-sympathicomimetic tocolysis.

摘要

在42名孕妇中研究了子宫下段β-拟交感神经药抑制宫缩对随后使用氟烷作为吸入麻醉剂进行剖宫产的影响。测量了手术期间的心率、血压和心脏活动。23名患者(“推注”组)接受了非诺特罗单一疗法。19名患者(“静脉抑制宫缩”组)使用非诺特罗联合心脏选择性β-1受体阻滞剂美托洛尔。与这两组相比,25名未进行抑制宫缩的孕妇作为对照接受检查。三组之间的心率和血压仅有轻微差异。42%的病例记录到心律失常,大多数情况发生在分娩前的浅麻醉期间。最常观察到心率为每分钟130次或更快的窦性心动过速。然而,异位性心律失常和窦性心动过缓很少见。剖宫产期间三组心律失常的发生率没有显著差异。没有证据表明β-拟交感神经药抑制宫缩后心律失常的发生率增加。

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