Traub E, Knoche E, Dick W, Jonatha W, Lindner K H
Geburtshilfe Frauenheilkd. 1982 Jan;42(1):11-5. doi: 10.1055/s-2008-1036612.
Beta-sympathomimetic tocolysis is an important part of modern obstetric therapy. Severe cardio-vascular complications have been described however, when inhalational anaesthesia was given following fenoterol-verapamil therapy. Alterations in clinical; cardiovascular parameters were measured in a prospective study on healthy women who had to undergo caesarean section and who had been treated with fenoterol-verapamil until the time of anaesthesia. The patients were given either halothane or enflurane as inhalational anaesthetic, and either an atropine premedication or none at all. Severe cardiovascular disturbances such as frequent extrasystole, arrhythmias or marked falls in blood pressure were not noted either during induction, whether following atropine or not, or during the course of anaesthesia with either 0.5 vol% halothane or 1.0 vol% enflurane.
β-拟交感神经药物抑制宫缩是现代产科治疗的重要组成部分。然而,已有报道称,在使用羟苄羟麻黄碱-维拉帕米治疗后进行吸入麻醉时会出现严重的心血管并发症。在一项前瞻性研究中,对必须接受剖宫产且在麻醉前接受过羟苄羟麻黄碱-维拉帕米治疗的健康女性,测量了临床心血管参数的变化。患者被给予氟烷或恩氟烷作为吸入麻醉剂,且要么进行阿托品术前用药,要么不进行任何术前用药。无论是在诱导期(无论是否使用阿托品),还是在使用0.5%体积分数的氟烷或1.0%体积分数的恩氟烷进行麻醉的过程中,均未观察到严重的心血管紊乱,如频发早搏、心律失常或显著的血压下降。