视网膜病理连接组学：神经退行性变的窗口。
Retinal Pathoconnectomics: A Window into Neurodegeneration.
机构信息
John A. Moran Eye Center, Department of Ophthalmology, University of Utah, Salt Lake City, UT, USA.
出版信息
Adv Exp Med Biol. 2023;1415:297-301. doi: 10.1007/978-3-031-27681-1_43.
Over the past decade, the field of retinal connectomics has made huge strides in describing the precise topologies underlying retinal visual processing. The same techniques that allowed these advancements are also applicable to understanding the progression of rewiring in retinal remodeling: retinal pathoconnectomics. Pathoconnectomics is unique in its unbiased approach to understanding the impacts of deafferentation on the remaining network components and identifying aberrant connectivities leading to visual processing defects. Pathoconnectomics also paves the way for identifying underlying rules of rewiring that may be recapitulated throughout the nervous system in other neurodegenerative diseases.
在过去的十年中，视网膜连接组学领域在描述视网膜视觉处理的精确拓扑结构方面取得了巨大的进展。允许这些进展的相同技术也适用于理解视网膜重塑中重新布线的进展：视网膜病理连接组学。病理连接组学在其理解去传入对剩余网络组件的影响以及识别导致视觉处理缺陷的异常连接的无偏方法方面是独特的。病理连接组学还为识别重新布线的潜在规则铺平了道路，这些规则可能在其他神经退行性疾病的整个神经系统中重现。
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