Department of Ophthalmology, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA.
Adv Exp Med Biol. 2023;1415:327-332. doi: 10.1007/978-3-031-27681-1_47.
The retinoic acid receptor-related orphan receptors (RORs) are ligand-mediated transcription factors with important biological roles in regulating circadian rhythms, metabolism, immunity, angiogenesis, inflammation, and development. They belong to the superfamily of nuclear receptors and include three family members: RORα, RORβ, and RORγ. Currently identified ROR ligands include cholesterol and cholesterol derivatives for RORα and RORγ, and stearic acid and all-trans retinoic acid for RORβ. Aberrant signaling of the RORs is involved in the pathogenesis of several human diseases including autoimmune diseases, metabolic disorders, and certain cancers. In the eye, RORs regulate normal development of the lens and the retina, and also contribute to potentially blinding eye diseases, especially retinal vascular diseases. Here, we review the role of RORs in eye development and disease to highlight their potential as druggable targets for therapeutic development in retinal vascular and degenerative diseases.
维甲酸相关孤儿受体（RORs）是配体介导的转录因子，在调节昼夜节律、代谢、免疫、血管生成、炎症和发育方面具有重要的生物学作用。它们属于核受体超家族，包括三个家族成员：RORα、RORβ 和 RORγ。目前已鉴定出的 ROR 配体包括胆固醇和胆固醇衍生物用于 RORα 和 RORγ，以及硬脂酸和全反式视黄酸用于 RORβ。ROR 的异常信号参与了几种人类疾病的发病机制，包括自身免疫性疾病、代谢紊乱和某些癌症。在眼睛中，ROR 调节晶状体和视网膜的正常发育，也有助于潜在致盲的眼部疾病，特别是视网膜血管疾病。在这里，我们综述了 ROR 在眼睛发育和疾病中的作用，以强调它们作为治疗视网膜血管和退行性疾病的药物靶点的潜力。
