视觉循环蛋白中的两亲性螺旋：综述。
The Amphipathic Helix in Visual Cycle Proteins: A Review.
机构信息
Laboratory of Retinal Cell and Molecular Biology, National Eye Institute, National Institutes of Health, Bethesda, MD, USA.
出版信息
Adv Exp Med Biol. 2023;1415:533-537. doi: 10.1007/978-3-031-27681-1_78.
The visual cycle is a complex biological process that involves the sequential action of proteins in the retinal pigment epithelial (RPE) cells and photoreceptors to modify and shuttle visual retinoids. A majority of the visual cycle proteins are membrane proteins, either integral or peripheral membrane proteins. Despite significant progress in understanding their physiological function, very limited structural information is available for the visual cycle proteins. Moreover, the mechanism of membrane interaction is not yet clear in all cases. Here, we demonstrate the presence of an amphipathic helix in selected RPE visual cycle proteins, using in silico tools, and highlight their role in membrane association and function.
视觉循环是一个复杂的生物学过程，涉及视网膜色素上皮 (RPE) 细胞和光感受器中蛋白质的顺序作用，以修饰和转运视觉类视黄醇。大多数视觉循环蛋白都是膜蛋白，无论是整合膜蛋白还是外周膜蛋白。尽管在理解它们的生理功能方面取得了重大进展，但对于视觉循环蛋白的结构信息非常有限。此外，在所有情况下，膜相互作用的机制尚不清楚。在这里，我们使用计算机模拟工具证明了在选定的 RPE 视觉循环蛋白中存在一个两亲性螺旋，并强调了它们在膜结合和功能中的作用。
Zotero 插件