Department of Laser Center, Hangzhou Third People's Hospital, Hangzhou 310009, Zhejiang, China.
Int J Clin Pract. 2023 Jun 26;2023:4081427. doi: 10.1155/2023/4081427. eCollection 2023.
The present study observed the therapeutic effect and possible side effects of Q-switch 1064-nm laser with large-spot and low-energy technology in the treatment of patients with combined freckles and chloasma.
A Q1064-nm laser with a large-spot diameter of 6-8 mm, energy level of 2.0-3.3 J/cm, frequency of 10 Hz, and pulse width of 10 ns was employed for the treatment. Each patient underwent treatment 10-15 times, with an interval of 10-15 days each time. Facial care was administered before and after treatment; attention was paid to cleaning and moisturizing, avoiding light, and using sunscreens strictly. The therapeutic effects were observed and evaluated.
Freckles basically subsided (effective rate = 100%) and chloasma faded (effective rate = 39.4%). Furthermore, whitening and delicacy improvement were observed in the surrounding normal skin area. After laser treatment, confocal laser scanning microscopy revealed a large number of melanin particles in the upper part of the granular layer. Moreover, the amount of melanin in the middle and lower parts of the basal layer and spinous layer was significantly decreased. None of the patients developed postinflammatory pigmentation.
In the treatment of freckles with chloasma, Q 1064-nm laser large-spot, low-energy technology not only removed freckles and faded chloasma but, most importantly, also reduced the incidence of postinflammatory pigmentation and improved patient satisfaction. This provided new methods and ideas for freckle laser treatment.
本研究观察了 Q 开关 1064nm 激光大光斑低能量技术治疗雀斑合并黄褐斑的疗效及可能出现的不良反应。
采用光斑直径 6-8mm，能量 2.0-3.3J/cm²，频率 10Hz，脉宽 10ns 的 Q1064nm 激光治疗，每个患者治疗 10-15 次，每次间隔 10-15d。治疗前后给予面部护理，注意清洁和保湿，避光，严格使用防晒霜。观察并评价疗效。
雀斑基本消退（有效率=100%），黄褐斑淡化（有效率=39.4%），同时观察到周围正常皮肤区域有美白、细腻改善。激光治疗后，共聚焦激光扫描显微镜显示大量黑素颗粒在上层颗粒层中。此外，基底细胞层和棘细胞层中下部的黑素含量明显减少。患者均无炎症后色素沉着。
Q 开关 1064nm 激光大光斑低能量技术治疗雀斑合并黄褐斑，不仅能去除雀斑，使黄褐斑淡化，更重要的是减少了炎症后色素沉着的发生，提高了患者满意度，为雀斑的激光治疗提供了新的方法和思路。
