Nakamura Ryohta, Hasegawa Go, Ikeda Yohei, Hara Noboru, Nishiyama Tsutomu
Department of Urology, Uonuma Institute of Community Medicine, Niigata University Medical and Dental Hospital, Minamiuonuma, Niigata, Japan.
Department of Pathology, Uonuma Institute of Community Medicine, Niigata University Medical and Dental Hospital, Minamiuonuma, Niigata, Japan.
SAGE Open Med Case Rep. 2023 Jun 30;11:2050313X231185444. doi: 10.1177/2050313X231185444. eCollection 2023.
An 82-year-old man was diagnosed with synchronous non-muscle-invasive bladder cancer and left lower ureteral carcinoma. He underwent transurethral resection of the bladder tumor, followed by total left nephroureterectomy after preoperative chemotherapy with four courses of gemcitabine and carboplatin. Histopathological findings showed positive-margin carcinoma in situ. In addition, since recurrence of non-muscle-invasive bladder cancer was observed in the bladder, Bacille Calmette-Guérin intravesical infusion therapy was performed, but the cancer persisted due to treatment resistance. After that, pembrolizumab therapy was performed, and complete remission was achieved.
一名82岁男性被诊断为同步性非肌层浸润性膀胱癌和左下腹段输尿管癌。他接受了经尿道膀胱肿瘤切除术，随后在接受了四个疗程的吉西他滨和顺铂术前化疗后进行了左侧全肾输尿管切除术。组织病理学检查结果显示切缘原位癌阳性。此外，由于在膀胱中观察到非肌层浸润性膀胱癌复发，遂进行了卡介苗膀胱内灌注治疗，但因治疗抵抗癌症持续存在。此后，进行了帕博利珠单抗治疗，并实现了完全缓解。
