Association Between and Gene Polymorphisms and Stroke Susceptibility in the Chinese Han Population.

BACKGROUND

Stroke has a high disability rate, and 30% of stroke cases have an unknown cause. Accurate diagnosis and treatment of stroke requires consideration of several rare heritable and non-heritable factors.

OBJECTIVE

This study aimed to evaluate the impacts of three genetic polymorphisms (rs369149111 in , rs1803628 in and rs9808753 in ) on stroke susceptibility among the Chinese Han population.

METHODS

Three single nucleotide polymorphisms (SNPs) from 623 stroke cases and 572 healthy controls were genotyped by the Agena MassARRAY platform. Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated by logistic regression analysis to evaluate the associations of three SNPs with stroke susceptibility. Additionally, SNP-SNP interactions were analyzed by multifactor dimensionality reduction (MDR).

RESULTS

As demonstrated by the overall analysis, rs9808753 in (allele: OR = 1.25, 95% CI = 1.06-1.47, = 0.007; homozygous: OR = 1.59, 95% CI = 1.14-2.23, = 0.007; dominant: OR = 1.31, 95% CI = 1.02-1.67, = 0.032; recessive: OR = 1.42, 95% CI = 1.05-1.91, = 0.022; additive: OR = 1.26, 95% CI = 1.07-1.48, = 0.007) was associated with an increased susceptibility to stroke. Besides, stratification analysis suggested that rs9808753 was associated with an increased risk of stroke in subgroup aged ≤ 64 years, males and drinkers ( < 0.05). And rs1803628 in was significantly associated with an increased susceptibility to stroke in non-smokers ( < 0.05).

CONCLUSION

A risk-increasing effect of rs980875 on stroke was detected in this study, which further broadens the understanding of the relationship between genetic polymorphisms and stroke susceptibility.