Department of Geriatrics, Xi'an Hospital of Traditional Chinese Medicine, Xi'an, 710021, Shaanxi, China.
Department of Encephalopathy, Xi'an Hospital of Traditional Chinese Medicine, Xi'an, 710021, Shaanxi, China.
Lipids Health Dis. 2020 Oct 12;19(1):221. doi: 10.1186/s12944-020-01370-z.
Stroke is a sudden disorder of cerebral blood circulation. Many studies have illustrated that dyslipidemia, hypertension, diabetes, smoking and excessive drinking are the traditional risk factors for stroke. This study aimed to observe the relationship between CYP1A1 and CYP1A2 variants and stroke risk in the Chinese population.
Agena MassARRAY Assay was used to genotype four single nucleotide polymorphisms (SNPs) in 477 cases and 480 controls. The chi-square test and logistic-regression analysis were used to explore the relationship between CYP1A1 and CYP1A2 variants and stroke risk.
Individuals with CYP1A2 rs762551 C was associated with a lower risk of stroke than that of allele A. Age stratification analysis showed that rs762551 was only observed to be associated with a lower risk of stroke in ≤64ys age group. After gender stratification analysis, a significant association between rs762551 and stroke risk was found in males, but not in females. The four SNPs were found to be correlated with stroke risk in patients with hypertension, coronary heart disease, cerebral infarction and lacunar infarction.
In this study, the results first showed that CYP1A1 and CYP1A2 variants were associated with stroke risk. Larger and well-designed studies are needed to confirm the results.
中风是一种突发性的大脑血液循环紊乱。许多研究表明，血脂异常、高血压、糖尿病、吸烟和酗酒是中风的传统危险因素。本研究旨在观察 CYP1A1 和 CYP1A2 变异与中国人群中风风险的关系。
采用 Agena MassARRAY assay 对 477 例病例和 480 例对照进行了四个单核苷酸多态性（SNPs）的基因分型。采用卡方检验和 logistic-regression 分析探讨 CYP1A1 和 CYP1A2 变异与中风风险的关系。
CYP1A2 rs762551 C 个体中风风险低于等位基因 A。年龄分层分析表明，rs762551 仅与≤64ys 年龄组中风风险降低相关。经性别分层分析，rs762551 与男性中风风险显著相关，而与女性无关。四项 SNP 与高血压、冠心病、脑梗死和腔隙性脑梗死患者的中风风险相关。
本研究首次表明 CYP1A1 和 CYP1A2 变异与中风风险相关。需要更大规模和设计良好的研究来证实这些结果。
