Tsuchiya M, Inoue S, Satta M, Yoshimura H, Arita M, Takamura Y
Nihon Yakurigaku Zasshi. 1986 Jun;87(6):649-54. doi: 10.1254/fpj.87.649.
Effect of an anorexiant, mazindol, on glucose absorption was investigated. Ten weeks-old female Sprague-Dawley rats were divided into mazindol treated (fed on powder diet containing 100 mg/kg of mazindol) and control groups. Four weeks later, experiments of continuous observation of glucose absorption and glucose transport were performed in each group using the everted sac method. During 180 min of continuous observation of glucose absorption, significantly lowered glucose concentrations of the serosal medium were observed in the mazindol treated group at oral and caudal ends of the upper, caudal end of the middle, and caudal ends of the lower small intestine, whereas no significant differences in glucose concentrations of the mucosal medium were observed between the two groups. After 60 min incubation for monitoring the glucose transport, significantly decreased glucose concentrations of serosal medium were observed in mazindol treated group at oral and caudal ends of the upper, caudal ends of the middle and caudal ends of the lower small intestine, whereas no significant differences in glucose concentrations of mucosal medium were observed. The results suggested that there is little effect on glucose absorption, but the metabolism of glucose or the remaining glucose in the small intestinal wall is increased by mazindol treatment.
研究了食欲抑制剂马吲哚对葡萄糖吸收的影响。将10周龄雌性斯普拉格-道利大鼠分为马吲哚处理组（喂食含100mg/kg马吲哚的粉末饲料）和对照组。四周后，每组采用外翻肠囊法进行葡萄糖吸收和葡萄糖转运的连续观察实验。在对葡萄糖吸收进行180分钟的连续观察期间，在马吲哚处理组的上小肠的口腔端和尾端、中肠的尾端以及下小肠的尾端，观察到浆膜介质中的葡萄糖浓度显著降低，而两组之间粘膜介质中的葡萄糖浓度没有显著差异。在孵育60分钟以监测葡萄糖转运后，在马吲哚处理组的上小肠的口腔端和尾端、中肠的尾端以及下小肠的尾端，观察到浆膜介质中的葡萄糖浓度显著降低，而粘膜介质中的葡萄糖浓度没有显著差异。结果表明，马吲哚处理对葡萄糖吸收影响不大，但会增加葡萄糖代谢或小肠壁中剩余的葡萄糖。
