Potezny N, McClure J, Rofe A M, Conyers R A
Food Chem Toxicol. 1986 May;24(5):389-96. doi: 10.1016/0278-6915(86)90203-6.
A prototype animal feeding model is described in which mice were meal-fed a balanced diet but were given free access to water (controls) or 20% (w/v) solutions of glucose, sucrose, fructose, xylitol or sorbitol. Under these conditions it was found that the provision of an alternative energy source, in the form of a refined carbohydrate, produced marked effects on total energy intake, mouse cube (i.e. balanced energy) intake and body weight. There were also changes in the metabolic states of the animals as assessed by serum levels of glucose, urea and cholesterol, plasma levels of lactate and D-3-hydroxybutyrate, and urinary excretion of urea and oxalate. Histological examinations of tissue indicated that the sucrose-fed mice had a tendency to suffer from acute congestion of the lungs and liver steatosis. Given a limited degree of dietary self-selection it appears that mice are more likely to be at risk of excessive food consumption and obesity when given glucose- or sucrose-containing diets than they are when fructose-, xylitol- or sorbitol-containing diets are given.
描述了一种原型动物喂养模型，其中给小鼠按餐喂食均衡饮食，但可自由饮水（对照组）或饮用20%（w/v）的葡萄糖、蔗糖、果糖、木糖醇或山梨醇溶液。在这些条件下发现，以精制碳水化合物形式提供替代能量源，对总能量摄入、小鼠方块饲料（即均衡能量）摄入和体重产生了显著影响。通过血清葡萄糖、尿素和胆固醇水平、血浆乳酸和D-3-羟基丁酸水平以及尿素和草酸盐的尿排泄量评估，动物的代谢状态也发生了变化。组织学检查表明，喂食蔗糖的小鼠有肺部急性充血和肝脂肪变性的倾向。在有限程度的饮食自我选择情况下，与给予含果糖、木糖醇或山梨醇的饮食相比，给予含葡萄糖或蔗糖的饮食时，小鼠似乎更有可能面临过度进食和肥胖的风险。
