Division of Veterinary Clinical Complex, FVSc & AH, Shuhama, J&K, 190006, India.
Division of Veterinary Surgery & Radiology, FVSc & AH, Shuhama, J&K, 190006, India.
Microb Pathog. 2023 Sep;182:106234. doi: 10.1016/j.micpath.2023.106234. Epub 2023 Jul 11.
Growing antimicrobial resistance (AMR) is a threat to human and animal populations citing the limited available options. Alternative antimicrobial options or functional enhancement of currently available antimicrobials remains only options. One of the potential options seems stem cells especially the mesenchymal stem cells (MSCs) that show antimicrobial properties. These cells additionally have pro-healing effects that may plausibly improve healing outcomes. MSCs antimicrobial actions are mediated either through direct cell-cell contact or their secretome that enhances innate immune mediated antimicrobial activities. These cells synergistically enhance efficacy of currently available antimicrobials especially against the biofilms. Reciprocal action from antimicrobials on the MSCs functionality remains poorly understood. Currently, the main limitation with MSCs based therapy is their limited efficacy. This demands further understanding and can be enhanced through biotechnological interventions. One of the interventional options is the 'priming' to enhance MSCs resistance and specific expression potential. The available literature shows potential antimicrobial actions of MSCs both ex vivo as well as in vivo. The studies on veterinary species are very promising although limited by number and extensiveness in details for their utility as standard therapeutic agents. The current review aims to discuss the role of animals in AMR and the potential antimicrobial actions of MSCs in veterinary medicine. The review also discusses the limitations in their utilization as standard therapeutics.
抗生素耐药性（AMR）的不断增长对人类和动物种群构成了威胁，因为现有的可用选择非常有限。替代抗生素选择或现有抗生素的功能增强仍然只是选择。一种潜在的选择似乎是干细胞，特别是间充质干细胞（MSCs），它们具有抗菌特性。这些细胞还具有促进愈合的作用，可能会改善愈合效果。MSCs 的抗菌作用是通过直接的细胞-细胞接触或其分泌组介导的，从而增强先天免疫介导的抗菌活性。这些细胞协同增强了现有抗生素的疗效，特别是针对生物膜。抗生素对 MSCs 功能的相互作用的影响仍知之甚少。目前，基于 MSC 的治疗的主要限制是其疗效有限。这需要进一步的理解，并可以通过生物技术干预来增强。干预的选择之一是“启动”以增强 MSCs 的耐药性和特定表达潜力。现有文献表明 MSCs 具有潜在的抗菌作用，无论是在体外还是体内。兽医物种的研究非常有前景，尽管由于数量和详细程度的限制，它们作为标准治疗剂的应用受到限制。本综述旨在讨论动物在 AMR 中的作用以及 MSCs 在兽医医学中的潜在抗菌作用。本文还讨论了将它们作为标准治疗药物的应用的局限性。
