Department of Anesthesia, Division of Pain Management, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, United States; Department of Anesthesiology, Washington University School of Medicine, St. Louis, MO, United States.
Department of Anesthesia, Division of Pain Management, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, United States; Department of Pediatrics, University of Cincinnati, College of Medicine, Cincinnati, OH, United States; Pediatric Pain Research Center, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, United States.
Brain Behav Immun. 2023 Oct;113:156-165. doi: 10.1016/j.bbi.2023.07.002. Epub 2023 Jul 11.
A peripheral injury drives neuroimmune interactions at the level of the injury and throughout the neuraxis. Understanding these systems will be beneficial in the pursuit to target persistent pain that involves both neural and immune components. In this review, we discuss the impact of injury on the development of neuroimmune signaling, along with data that suggest a possible cellular immune memory. We also discuss the parallel effects of injury in the nervous system and immune related areas including bone marrow, lymph node and central nervous system-related cells. Finally, we relate these findings to patient populations and current research that evaluates human tissue.
外周损伤会在损伤部位和整个神经系统引发神经免疫相互作用。了解这些系统对于靶向涉及神经和免疫成分的持续性疼痛将是有益的。在这篇综述中，我们讨论了损伤对神经免疫信号转导发展的影响，以及表明可能存在细胞免疫记忆的数据。我们还讨论了损伤在神经系统和免疫相关区域（包括骨髓、淋巴结和中枢神经系统相关细胞）中的平行效应。最后，我们将这些发现与患者群体和评估人类组织的当前研究联系起来。
