Henan Key Laboratory of Rare Diseases, Endocrinology and Metabolism Center, The First Affiliated Hospital and College of Clinical Medicine of Henan of Science and Technology, Luoyang, China.
Department of Endocrinology, Anhui Provincial Hospital Affiliated to Anhui Medical University, Hefei, China.
Lipids Health Dis. 2023 Jul 13;22(1):102. doi: 10.1186/s12944-023-01865-5.
Increased levels of low-density lipoprotein cholesterol (LDL-C) have been identified as one potential risk factor for diabetic peripheral neuropathy (DPN) in patients. The current study seeks to clarify the link between LDL-C, hyperglycemia, and DPN in patients with type 2 diabetes mellitus (T2DM).
Here, a total of 120 T2DM individuals were recruited. These volunteers with T2DM were divided into 2 groups, based on the presence or absence of peripheral neuropathy. Additionally, their baseline characteristics were compared. Association among LDL-C and glycosylated hemoglobin (HbA1c) levels and DPN, particularly with respect to specific nerve conduction velocity were analyzed. To identify factors influencing DPN, regression was performed. Furthermore, mediation analysis was employed to evaluate the indirect, direct and total effects of LDL-C on specific nerve conduction velocity, with HbA1c serving as a mediator.
Compared to 55 patients without DPN, 65 patients with DPN demonstrated elevated levels of LDL-C and HbA1c. Both LDL-C and HbA1c have been found to be associated with reduced the motor fiber conduction velocities of Ulnar (or the Common peroneal) nerve in diabetic patients. HbA1c is one of the known risk factors for DPN in individuals with T2DM. Further mediation analysis revealed that the effect of LDL-C on the Ulnar (or the Common peroneal) nerve motor fiber conduction velocities are fully mediated by HbA1c in patients with T2DM.
The impact of elevated LDL-C levels upon the Ulnar (or the Common peroneal) nerve motor fiber conduction velocities in patients with T2DM was found to be entirely mediated by increased HbA1c levels.
低密度脂蛋白胆固醇（LDL-C）水平升高已被确定为糖尿病周围神经病变（DPN）患者的潜在危险因素之一。本研究旨在阐明 2 型糖尿病（T2DM）患者的 LDL-C、高血糖与 DPN 之间的关系。
共纳入 120 例 T2DM 患者。这些 T2DM 志愿者根据是否存在周围神经病变分为两组，并比较其基线特征。分析 LDL-C 与糖化血红蛋白（HbA1c）水平与 DPN 的关系，特别是与特定神经传导速度的关系。采用回归分析确定影响 DPN 的因素。此外，还进行了中介分析，以评估 LDL-C 对特定神经传导速度的间接、直接和总效应，以 HbA1c 为中介。
与 55 例无 DPN 的患者相比，65 例有 DPN 的患者 LDL-C 和 HbA1c 水平升高。LDL-C 和 HbA1c 均与糖尿病患者尺神经（或腓总神经）运动纤维传导速度降低相关。HbA1c 是 T2DM 患者 DPN 的已知危险因素之一。进一步的中介分析显示，LDL-C 对 T2DM 患者尺神经（或腓总神经）运动纤维传导速度的影响完全由 HbA1c 介导。
T2DM 患者 LDL-C 水平升高对尺神经（或腓总神经）运动纤维传导速度的影响完全由 HbA1c 水平升高介导。
